FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050663323> ?p ?o ?g. }

• W2050663323 endingPage "3614" @default.
• W2050663323 startingPage "3609" @default.
• W2050663323 abstract "Leptin is a fat cell-derived hormone that regulates food intake and energy expenditure. We previously demonstrated that leptin is produced by nonadipose cells, i.e. by placental trophoblasts. We also reported that a human trophoblastic cell line, BeWo cells, expresses leptin gene and secretes leptin into culture media. To elucidate the regulatory mechanisms of leptin production by human trophoblasts, we investigated synthesis and secretion of leptin in BeWo cells and in explant cultures of human placental tissue. Leptin production and gene expression in BeWo cells were increased by treatment with forskolin. The forskolin-induced increase in leptin production was completely suppressed by H89, an inhibitor of protein kinase A. Leptin production and gene expression in BeWo cells were increased by treatment with phorbol myristate acetate (PMA). The PMA-induced increase in leptin production was completely suppressed by H7 and staurosporine, both of which are inhibitors of protein kinase C. Leptin secretion from first trimester chorionic tissue was approximately 50-fold greater than that from term placental tissue. Leptin production and gene expression in explant cultures of placental tissue at both stages of pregnancy were augmented markedly by treatment with forskolin or PMA. The present study demonstrated augmentation of leptin production by protein kinase A and protein kinase C in cultured human trophoblasts, thereby leading to a better understanding of the regulatory mechanisms of leptin production in human trophoblasts in vivo." @default.
• W2050663323 created "2016-06-24" @default.
• W2050663323 creator A5012652138 @default.
• W2050663323 creator A5018854168 @default.
• W2050663323 creator A5020992072 @default.
• W2050663323 creator A5028562352 @default.
• W2050663323 creator A5033980070 @default.
• W2050663323 creator A5043952560 @default.
• W2050663323 creator A5063826570 @default.
• W2050663323 creator A5064836525 @default.
• W2050663323 creator A5074060371 @default.
• W2050663323 date "1998-10-01" @default.
• W2050663323 modified "2023-09-26" @default.
• W2050663323 title "Augmentation of Leptin Synthesis and Secretion Through Activation of Protein Kinases A and C in Cultured Human Trophoblastic Cells1" @default.
• W2050663323 cites W1481438484 @default.
• W2050663323 cites W1542067030 @default.
• W2050663323 cites W1582375112 @default.
• W2050663323 cites W1589866689 @default.
• W2050663323 cites W1898841977 @default.
• W2050663323 cites W1969250188 @default.
• W2050663323 cites W1971555965 @default.
• W2050663323 cites W1973454785 @default.
• W2050663323 cites W1974617156 @default.
• W2050663323 cites W1975199641 @default.
• W2050663323 cites W1981449370 @default.
• W2050663323 cites W1981677358 @default.
• W2050663323 cites W1989042685 @default.
• W2050663323 cites W1993088616 @default.
• W2050663323 cites W1996713062 @default.
• W2050663323 cites W2002751882 @default.
• W2050663323 cites W2004197857 @default.
• W2050663323 cites W2009436719 @default.
• W2050663323 cites W2013583119 @default.
• W2050663323 cites W2014050305 @default.
• W2050663323 cites W2015043542 @default.
• W2050663323 cites W2020802597 @default.
• W2050663323 cites W2032123298 @default.
• W2050663323 cites W2069635660 @default.
• W2050663323 cites W2078506029 @default.
• W2050663323 cites W2080244403 @default.
• W2050663323 cites W2087471473 @default.
• W2050663323 cites W2090390027 @default.
• W2050663323 cites W2093371722 @default.
• W2050663323 cites W2094830591 @default.
• W2050663323 cites W2097367460 @default.
• W2050663323 cites W2101921785 @default.
• W2050663323 cites W2104012044 @default.
• W2050663323 cites W2129351675 @default.
• W2050663323 cites W2148969624 @default.
• W2050663323 cites W2189016857 @default.
• W2050663323 cites W2334337188 @default.
• W2050663323 doi "https://doi.org/10.1210/jcem.83.10.5181" @default.
• W2050663323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9768673" @default.
• W2050663323 hasPublicationYear "1998" @default.
• W2050663323 type Work @default.
• W2050663323 sameAs 2050663323 @default.
• W2050663323 citedByCount "18" @default.
• W2050663323 countsByYear W20506633232012 @default.
• W2050663323 countsByYear W20506633232013 @default.
• W2050663323 countsByYear W20506633232015 @default.
• W2050663323 crossrefType "journal-article" @default.
• W2050663323 hasAuthorship W2050663323A5012652138 @default.
• W2050663323 hasAuthorship W2050663323A5018854168 @default.
• W2050663323 hasAuthorship W2050663323A5020992072 @default.
• W2050663323 hasAuthorship W2050663323A5028562352 @default.
• W2050663323 hasAuthorship W2050663323A5033980070 @default.
• W2050663323 hasAuthorship W2050663323A5043952560 @default.
• W2050663323 hasAuthorship W2050663323A5063826570 @default.
• W2050663323 hasAuthorship W2050663323A5064836525 @default.
• W2050663323 hasAuthorship W2050663323A5074060371 @default.
• W2050663323 hasBestOaLocation W20506633231 @default.
• W2050663323 hasConcept C126322002 @default.
• W2050663323 hasConcept C134018914 @default.
• W2050663323 hasConcept C172680121 @default.
• W2050663323 hasConcept C184235292 @default.
• W2050663323 hasConcept C185592680 @default.
• W2050663323 hasConcept C195794163 @default.
• W2050663323 hasConcept C24998067 @default.
• W2050663323 hasConcept C2776953305 @default.
• W2050663323 hasConcept C2779084600 @default.
• W2050663323 hasConcept C2779234561 @default.
• W2050663323 hasConcept C2779276759 @default.
• W2050663323 hasConcept C2780613262 @default.
• W2050663323 hasConcept C49039625 @default.
• W2050663323 hasConcept C511355011 @default.
• W2050663323 hasConcept C54355233 @default.
• W2050663323 hasConcept C71924100 @default.
• W2050663323 hasConcept C81885089 @default.
• W2050663323 hasConcept C86803240 @default.
• W2050663323 hasConcept C95444343 @default.
• W2050663323 hasConcept C97029542 @default.
• W2050663323 hasConceptScore W2050663323C126322002 @default.
• W2050663323 hasConceptScore W2050663323C134018914 @default.
• W2050663323 hasConceptScore W2050663323C172680121 @default.
• W2050663323 hasConceptScore W2050663323C184235292 @default.
• W2050663323 hasConceptScore W2050663323C185592680 @default.
• W2050663323 hasConceptScore W2050663323C195794163 @default.
• W2050663323 hasConceptScore W2050663323C24998067 @default.

• next