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• W2050665616 abstract "In situ gastric absorption rate constants determined in rats for a series of phenylalkylcarboxylic acids in free solution were correlated with in vitro lipophilicity indexes. The correlations were bilinear in nature, in contrast with what occurs in other digestive absorption sites, where such correlations are always of the hyperbolic type. Bilinear correlations are found when heterogeneous barrier systems prevail at the absorption site; this conception seems to be in close agreement with the novel approaches describing the structure of the gastric mucosal surface, according to which a lipid lining of natural amphiphiles provides the mucosal surface with a physiological protection against its highly acid environment. This structure is not found in the intestinal mucosae, which act as homogeneous barrier systems. In the presence of surfactants in gastric perfusion fluids, the correlations became similar to those found in nonspecialized absorption sites such as colon. This would mean that the hydrophobic lining is disrupted by surfactants, thus leaving unprotected the absorbing membrane, which is then exposed to the aggressive surrounding medium. Physiological and pathological implications derived from these observations are discussed." @default.
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• W2050665616 date "1990-10-01" @default.
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• W2050665616 title "Gastric absorption of acidic xenobiotics in the rat: Biophysical interpretation of an apparently atypical behaviour" @default.
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• W2050665616 doi "https://doi.org/10.1016/0378-5173(90)90261-2" @default.
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