FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050666593> ?p ?o ?g. }

• W2050666593 endingPage "51" @default.
• W2050666593 startingPage "44" @default.
• W2050666593 abstract "Previous studies indicate that noise induced hearing loss (NIHL) involves a decrease in glutathione peroxidase (GPx) activity and a subsequent loss of outer hair cells (OHC). However, the cellular localization of this GPx decrease and the link to OHC loss are still poorly understood. In this report, we examined the cellular localization of GPx (GPx1, GPx 3 and GPx 4) in F-344 rat before and after noise exposure and after oral treatment with ebselen, a small molecule mimic of GPx activity. Results indicate that GPx1 is the major isoform within the cochlea and is highly expressed in cells of the organ of Corti, spiral ganglia, stria vascularis, and spiral ligament. Within 5h of noise exposure (4h at 113 dB, 4-16 kHz), significant OHC loss was already apparent in regions coincident with the 8-16 kHz region of the cochlea. In addition, the stria vascularis exhibited significant edema or swelling and a decrease in GPx1 immunoreactivity or fluorescent intensity. Treatment with ebselen (4 mg/kg p.o.) before and immediately after noise exposure reduced both OHC loss and the swelling of the stria vascularis typically observed within 5h post-noise exposure. Interestingly, GPx1 levels increased in the stria vascularis after noise and ebselen treatment vs noise and vehicle-only treatment, and exceeded baseline no noise control levels. These data indicate that ebselen acts to prevent the acute loss of OHCs and reduces the acute swelling of the stria vascularis by two potential mechanisms: one, as a ROS/RNS scavenger through its intrinsic GPx activity, and two, as a stimulator of GPx1 expression or activity. This latter mechanism may be due to the preservation of endogenous GPx1 from ROS/RNS induced degradation and/or the stimulation of GPx1 expression or activity." @default.
• W2050666593 created "2016-06-24" @default.
• W2050666593 creator A5021419377 @default.
• W2050666593 creator A5037267803 @default.
• W2050666593 creator A5051788299 @default.
• W2050666593 creator A5055011838 @default.
• W2050666593 creator A5082513291 @default.
• W2050666593 date "2007-04-01" @default.
• W2050666593 modified "2023-09-24" @default.
• W2050666593 title "Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase" @default.
• W2050666593 cites W1527264774 @default.
• W2050666593 cites W1963778474 @default.
• W2050666593 cites W1969553244 @default.
• W2050666593 cites W1978284525 @default.
• W2050666593 cites W1985499785 @default.
• W2050666593 cites W1986584051 @default.
• W2050666593 cites W1987363301 @default.
• W2050666593 cites W2013397458 @default.
• W2050666593 cites W2016853025 @default.
• W2050666593 cites W2026314813 @default.
• W2050666593 cites W2035258484 @default.
• W2050666593 cites W2046207757 @default.
• W2050666593 cites W2058674735 @default.
• W2050666593 cites W2060938234 @default.
• W2050666593 cites W2063544163 @default.
• W2050666593 cites W2070276025 @default.
• W2050666593 cites W2071287111 @default.
• W2050666593 cites W2075639702 @default.
• W2050666593 cites W2078045632 @default.
• W2050666593 cites W2085793489 @default.
• W2050666593 cites W2107442441 @default.
• W2050666593 cites W2112330276 @default.
• W2050666593 cites W2112693462 @default.
• W2050666593 cites W2113803576 @default.
• W2050666593 cites W2114557855 @default.
• W2050666593 cites W2166924755 @default.
• W2050666593 cites W2268695670 @default.
• W2050666593 cites W306944446 @default.
• W2050666593 doi "https://doi.org/10.1016/j.heares.2006.08.006" @default.
• W2050666593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17030476" @default.
• W2050666593 hasPublicationYear "2007" @default.
• W2050666593 type Work @default.
• W2050666593 sameAs 2050666593 @default.
• W2050666593 citedByCount "118" @default.
• W2050666593 countsByYear W20506665932012 @default.
• W2050666593 countsByYear W20506665932013 @default.
• W2050666593 countsByYear W20506665932014 @default.
• W2050666593 countsByYear W20506665932015 @default.
• W2050666593 countsByYear W20506665932016 @default.
• W2050666593 countsByYear W20506665932017 @default.
• W2050666593 countsByYear W20506665932018 @default.
• W2050666593 countsByYear W20506665932019 @default.
• W2050666593 countsByYear W20506665932020 @default.
• W2050666593 countsByYear W20506665932021 @default.
• W2050666593 countsByYear W20506665932022 @default.
• W2050666593 countsByYear W20506665932023 @default.
• W2050666593 crossrefType "journal-article" @default.
• W2050666593 hasAuthorship W2050666593A5021419377 @default.
• W2050666593 hasAuthorship W2050666593A5037267803 @default.
• W2050666593 hasAuthorship W2050666593A5051788299 @default.
• W2050666593 hasAuthorship W2050666593A5055011838 @default.
• W2050666593 hasAuthorship W2050666593A5082513291 @default.
• W2050666593 hasConcept C105702510 @default.
• W2050666593 hasConcept C126322002 @default.
• W2050666593 hasConcept C134018914 @default.
• W2050666593 hasConcept C185592680 @default.
• W2050666593 hasConcept C203663253 @default.
• W2050666593 hasConcept C2775838275 @default.
• W2050666593 hasConcept C2776151105 @default.
• W2050666593 hasConcept C2778760513 @default.
• W2050666593 hasConcept C2779138974 @default.
• W2050666593 hasConcept C2779356876 @default.
• W2050666593 hasConcept C2780130748 @default.
• W2050666593 hasConcept C2780408329 @default.
• W2050666593 hasConcept C2780493683 @default.
• W2050666593 hasConcept C2780659331 @default.
• W2050666593 hasConcept C3018332767 @default.
• W2050666593 hasConcept C548259974 @default.
• W2050666593 hasConcept C71924100 @default.
• W2050666593 hasConceptScore W2050666593C105702510 @default.
• W2050666593 hasConceptScore W2050666593C126322002 @default.
• W2050666593 hasConceptScore W2050666593C134018914 @default.
• W2050666593 hasConceptScore W2050666593C185592680 @default.
• W2050666593 hasConceptScore W2050666593C203663253 @default.
• W2050666593 hasConceptScore W2050666593C2775838275 @default.
• W2050666593 hasConceptScore W2050666593C2776151105 @default.
• W2050666593 hasConceptScore W2050666593C2778760513 @default.
• W2050666593 hasConceptScore W2050666593C2779138974 @default.
• W2050666593 hasConceptScore W2050666593C2779356876 @default.
• W2050666593 hasConceptScore W2050666593C2780130748 @default.
• W2050666593 hasConceptScore W2050666593C2780408329 @default.
• W2050666593 hasConceptScore W2050666593C2780493683 @default.
• W2050666593 hasConceptScore W2050666593C2780659331 @default.
• W2050666593 hasConceptScore W2050666593C3018332767 @default.
• W2050666593 hasConceptScore W2050666593C548259974 @default.
• W2050666593 hasConceptScore W2050666593C71924100 @default.
• W2050666593 hasIssue "1-2" @default.
• W2050666593 hasLocation W20506665931 @default.

• next