FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050668495> ?p ?o ?g. }

• W2050668495 endingPage "2645" @default.
• W2050668495 startingPage "2638" @default.
• W2050668495 abstract "This study was performed in the aim to identify potential targets for the development of novel therapy to treat cancer with poor outcome or treatment efficacy. We show that the negatively charged phospholipid phosphatidylserine (PS) is exposed in the outer leaflet of their plasma membrane not only in tumor cell lines, but also in metastases and primary cultures thereof, which contrasts with a lack of PS exposure by differentiated non-tumorigenic counterparts. Studied tumor cell lines were derived from non-tumorigenic and malignant melanomas, prostate- and renal cancer, glioblastoma and a rhabdomyosarcoma. Importantly, also metastases of melanoma expose PS and there is a correlation between malignancy of melanoma cell lines from different stages of tumor progression and PS exposure. The PS exposure we found was neither of apoptotic nor of experimental artificial origin. Finally potentially malignant and non-malignant cells could be differentiated by sorting of a primary cell culture derived from a glioblastoma based on PS exposure, which has so far not been possible within one culture due to lack of a specific marker. Our data provide clear evidence that PS could serve as uniform marker of tumor cells and metastases as well as a target for novel therapeutic approaches based on e.g. PS-specific host defense derived peptides." @default.
• W2050668495 created "2016-06-24" @default.
• W2050668495 creator A5004792898 @default.
• W2050668495 creator A5022178831 @default.
• W2050668495 creator A5026630577 @default.
• W2050668495 creator A5030954867 @default.
• W2050668495 creator A5042119021 @default.
• W2050668495 creator A5079759046 @default.
• W2050668495 creator A5081553510 @default.
• W2050668495 creator A5090515176 @default.
• W2050668495 date "2011-11-01" @default.
• W2050668495 modified "2023-10-11" @default.
• W2050668495 title "In search of a novel target — Phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy" @default.
• W2050668495 cites W1525900448 @default.
• W2050668495 cites W1533153036 @default.
• W2050668495 cites W1561591381 @default.
• W2050668495 cites W1591166893 @default.
• W2050668495 cites W165853039 @default.
• W2050668495 cites W16631805 @default.
• W2050668495 cites W1914088945 @default.
• W2050668495 cites W1924003041 @default.
• W2050668495 cites W1940692702 @default.
• W2050668495 cites W1963606380 @default.
• W2050668495 cites W1964740804 @default.
• W2050668495 cites W1981566975 @default.
• W2050668495 cites W1990356838 @default.
• W2050668495 cites W1996849584 @default.
• W2050668495 cites W1997963851 @default.
• W2050668495 cites W2007744639 @default.
• W2050668495 cites W2009592988 @default.
• W2050668495 cites W2012815507 @default.
• W2050668495 cites W2027214066 @default.
• W2050668495 cites W2030701238 @default.
• W2050668495 cites W2032055408 @default.
• W2050668495 cites W2045743453 @default.
• W2050668495 cites W2054602599 @default.
• W2050668495 cites W2057916782 @default.
• W2050668495 cites W2058037164 @default.
• W2050668495 cites W2060759428 @default.
• W2050668495 cites W2071741411 @default.
• W2050668495 cites W2072182813 @default.
• W2050668495 cites W2082063496 @default.
• W2050668495 cites W2092822354 @default.
• W2050668495 cites W2100621506 @default.
• W2050668495 cites W2101322634 @default.
• W2050668495 cites W2111642082 @default.
• W2050668495 cites W2145135643 @default.
• W2050668495 cites W2163126616 @default.
• W2050668495 cites W2166291746 @default.
• W2050668495 cites W2170792377 @default.
• W2050668495 doi "https://doi.org/10.1016/j.bbamem.2011.07.026" @default.
• W2050668495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3175029" @default.
• W2050668495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21810406" @default.
• W2050668495 hasPublicationYear "2011" @default.
• W2050668495 type Work @default.
• W2050668495 sameAs 2050668495 @default.
• W2050668495 citedByCount "259" @default.
• W2050668495 countsByYear W20506684952012 @default.
• W2050668495 countsByYear W20506684952013 @default.
• W2050668495 countsByYear W20506684952014 @default.
• W2050668495 countsByYear W20506684952015 @default.
• W2050668495 countsByYear W20506684952016 @default.
• W2050668495 countsByYear W20506684952017 @default.
• W2050668495 countsByYear W20506684952018 @default.
• W2050668495 countsByYear W20506684952019 @default.
• W2050668495 countsByYear W20506684952020 @default.
• W2050668495 countsByYear W20506684952021 @default.
• W2050668495 countsByYear W20506684952022 @default.
• W2050668495 countsByYear W20506684952023 @default.
• W2050668495 crossrefType "journal-article" @default.
• W2050668495 hasAuthorship W2050668495A5004792898 @default.
• W2050668495 hasAuthorship W2050668495A5022178831 @default.
• W2050668495 hasAuthorship W2050668495A5026630577 @default.
• W2050668495 hasAuthorship W2050668495A5030954867 @default.
• W2050668495 hasAuthorship W2050668495A5042119021 @default.
• W2050668495 hasAuthorship W2050668495A5079759046 @default.
• W2050668495 hasAuthorship W2050668495A5081553510 @default.
• W2050668495 hasAuthorship W2050668495A5090515176 @default.
• W2050668495 hasBestOaLocation W20506684951 @default.
• W2050668495 hasConcept C121608353 @default.
• W2050668495 hasConcept C126322002 @default.
• W2050668495 hasConcept C142724271 @default.
• W2050668495 hasConcept C190283241 @default.
• W2050668495 hasConcept C203014093 @default.
• W2050668495 hasConcept C2777658100 @default.
• W2050668495 hasConcept C2778918659 @default.
• W2050668495 hasConcept C2779399171 @default.
• W2050668495 hasConcept C2779637612 @default.
• W2050668495 hasConcept C41625074 @default.
• W2050668495 hasConcept C502942594 @default.
• W2050668495 hasConcept C54355233 @default.
• W2050668495 hasConcept C553184892 @default.
• W2050668495 hasConcept C55493867 @default.
• W2050668495 hasConcept C71924100 @default.
• W2050668495 hasConcept C81885089 @default.
• W2050668495 hasConcept C86803240 @default.
• W2050668495 hasConcept C88634738 @default.
• W2050668495 hasConceptScore W2050668495C121608353 @default.

• next