FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050672068> ?p ?o ?g. }

• W2050672068 endingPage "6100" @default.
• W2050672068 startingPage "6091" @default.
• W2050672068 abstract "Phosphodiesterases (PDEs) are enzymes that modulate cyclic nucleotide signaling and as such are clinical targets for a range of disorders including congestive heart failure, erectile dysfunction, and inflammation. The PDE3 family comprises two highly homologous subtypes expressed in different tissues, and inhibitors of this family have been shown to increase lipolysis in adipocytes. A specific PDE3B (the lipocyte-localized subtype) inhibitor would be a very useful tool to evaluate the effects of PDE3 inhibition on lipolysis and metabolic rate and might become a novel tool for treatment of obesity. We report here the three-dimensional structures of the catalytic domain of human PDE3B in complex with a generic PDE inhibitor and a novel PDE3 selective inhibitor. These structures explain the dual cAMP/cGMP binding capabilities of PDE3, provide the molecular basis for inhibitor specificity, and can supply a valid platform for the design of improved compounds." @default.
• W2050672068 created "2016-06-24" @default.
• W2050672068 creator A5016977874 @default.
• W2050672068 creator A5028338622 @default.
• W2050672068 creator A5037639534 @default.
• W2050672068 creator A5037784065 @default.
• W2050672068 creator A5050475544 @default.
• W2050672068 creator A5055675220 @default.
• W2050672068 creator A5069974203 @default.
• W2050672068 creator A5079637150 @default.
• W2050672068 creator A5080459908 @default.
• W2050672068 creator A5084379862 @default.
• W2050672068 creator A5086735835 @default.
• W2050672068 date "2004-04-27" @default.
• W2050672068 modified "2023-10-01" @default.
• W2050672068 title "Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity" @default.
• W2050672068 cites W1576798989 @default.
• W2050672068 cites W1963851797 @default.
• W2050672068 cites W2016066239 @default.
• W2050672068 cites W2035690299 @default.
• W2050672068 cites W2059831521 @default.
• W2050672068 cites W2064227075 @default.
• W2050672068 cites W2097493124 @default.
• W2050672068 cites W2132124951 @default.
• W2050672068 cites W2142889758 @default.
• W2050672068 cites W2166389885 @default.
• W2050672068 cites W2168221437 @default.
• W2050672068 doi "https://doi.org/10.1021/bi049868i" @default.
• W2050672068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15147193" @default.
• W2050672068 hasPublicationYear "2004" @default.
• W2050672068 type Work @default.
• W2050672068 sameAs 2050672068 @default.
• W2050672068 citedByCount "100" @default.
• W2050672068 countsByYear W20506720682012 @default.
• W2050672068 countsByYear W20506720682013 @default.
• W2050672068 countsByYear W20506720682014 @default.
• W2050672068 countsByYear W20506720682015 @default.
• W2050672068 countsByYear W20506720682016 @default.
• W2050672068 countsByYear W20506720682017 @default.
• W2050672068 countsByYear W20506720682018 @default.
• W2050672068 countsByYear W20506720682019 @default.
• W2050672068 countsByYear W20506720682020 @default.
• W2050672068 countsByYear W20506720682021 @default.
• W2050672068 countsByYear W20506720682022 @default.
• W2050672068 countsByYear W20506720682023 @default.
• W2050672068 crossrefType "journal-article" @default.
• W2050672068 hasAuthorship W2050672068A5016977874 @default.
• W2050672068 hasAuthorship W2050672068A5028338622 @default.
• W2050672068 hasAuthorship W2050672068A5037639534 @default.
• W2050672068 hasAuthorship W2050672068A5037784065 @default.
• W2050672068 hasAuthorship W2050672068A5050475544 @default.
• W2050672068 hasAuthorship W2050672068A5055675220 @default.
• W2050672068 hasAuthorship W2050672068A5069974203 @default.
• W2050672068 hasAuthorship W2050672068A5079637150 @default.
• W2050672068 hasAuthorship W2050672068A5080459908 @default.
• W2050672068 hasAuthorship W2050672068A5084379862 @default.
• W2050672068 hasAuthorship W2050672068A5086735835 @default.
• W2050672068 hasConcept C103697762 @default.
• W2050672068 hasConcept C126322002 @default.
• W2050672068 hasConcept C134018914 @default.
• W2050672068 hasConcept C140985366 @default.
• W2050672068 hasConcept C171089720 @default.
• W2050672068 hasConcept C181199279 @default.
• W2050672068 hasConcept C185592680 @default.
• W2050672068 hasConcept C2779929075 @default.
• W2050672068 hasConcept C2780215583 @default.
• W2050672068 hasConcept C55493867 @default.
• W2050672068 hasConcept C58141971 @default.
• W2050672068 hasConcept C62826618 @default.
• W2050672068 hasConcept C71924100 @default.
• W2050672068 hasConcept C74187038 @default.
• W2050672068 hasConcept C74534348 @default.
• W2050672068 hasConcept C86803240 @default.
• W2050672068 hasConcept C95444343 @default.
• W2050672068 hasConcept C98274493 @default.
• W2050672068 hasConceptScore W2050672068C103697762 @default.
• W2050672068 hasConceptScore W2050672068C126322002 @default.
• W2050672068 hasConceptScore W2050672068C134018914 @default.
• W2050672068 hasConceptScore W2050672068C140985366 @default.
• W2050672068 hasConceptScore W2050672068C171089720 @default.
• W2050672068 hasConceptScore W2050672068C181199279 @default.
• W2050672068 hasConceptScore W2050672068C185592680 @default.
• W2050672068 hasConceptScore W2050672068C2779929075 @default.
• W2050672068 hasConceptScore W2050672068C2780215583 @default.
• W2050672068 hasConceptScore W2050672068C55493867 @default.
• W2050672068 hasConceptScore W2050672068C58141971 @default.
• W2050672068 hasConceptScore W2050672068C62826618 @default.
• W2050672068 hasConceptScore W2050672068C71924100 @default.
• W2050672068 hasConceptScore W2050672068C74187038 @default.
• W2050672068 hasConceptScore W2050672068C74534348 @default.
• W2050672068 hasConceptScore W2050672068C86803240 @default.
• W2050672068 hasConceptScore W2050672068C95444343 @default.
• W2050672068 hasConceptScore W2050672068C98274493 @default.
• W2050672068 hasIssue "20" @default.
• W2050672068 hasLocation W20506720681 @default.
• W2050672068 hasLocation W20506720682 @default.
• W2050672068 hasOpenAccess W2050672068 @default.
• W2050672068 hasPrimaryLocation W20506720681 @default.

• next