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- W2050672110 abstract "Transfer RNAs (tRNAs) are ancient macromolecules that have evolved under various environmental pressures as adaptors in translation in all forms of life but also towards alternative structures and functions. The present knowledge on both canonical and deviating signature motifs retrieved from vertical and horizontal sequence comparisons is briefly reviewed. Novel characteristics, proper to tRNAs from a given translation system, are revealed by a case study on the nuclear and organellar tRNA sets from malaria-related organisms. Unprecedented distinctive features for Plasmodium falciparum apicoplastic tRNAs appear, which provide novel routes to be explored towards anti-malarial drugs. The ongoing high-throughput sequencing programs are expected to allow for further horizontal comparisons and to reveal other signatures of either full or restricted sets of tRNAs." @default.
- W2050672110 created "2016-06-24" @default.
- W2050672110 creator A5054694568 @default.
- W2050672110 creator A5056945337 @default.
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- W2050672110 date "2009-11-19" @default.
- W2050672110 modified "2023-10-17" @default.
- W2050672110 title "Diversity and similarity in the tRNA world: Overall view and case study on malaria-related tRNAs" @default.
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- W2050672110 doi "https://doi.org/10.1016/j.febslet.2009.11.050" @default.
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