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- W2050674330 abstract "To elucidate the mechanism of the interaction of basic drugs with Na + -dependent L-alanine absorption from the small intestine, we investigated the effect of imipramine on the transport of L-alanine via system B 0 , which is thought to be one of the main Na + -dependent systems for intestinal absorption of short-chain neutral amino acids, including L-alanine. The uptake of L-alanine by cells that express hATB 0 (human amino acid transporter B 0 ) was inhibited in the presence of imipramine. The Eadie-Hofstee plot showed that the inhibition was not competitive with the substrate (L-alanine) but competitive with Na + . When rat intestinal brush border membrane vesicles were used, several basic drugs had inhibitory effects. Inhibition was also observed in intestinal absorption evaluated by an in situ single-pass perfusion technique. However, the potencies of inhibition were different. The potency of inhibition was dependent on the lipophilicity of the drugs." @default.
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- W2050674330 date "2003-01-01" @default.
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- W2050674330 title "Inhibitory Effects of Basic Drugs on the Sodium-Dependent Transport of L-Alanine via System B0 in the Small Intestine" @default.
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- W2050674330 doi "https://doi.org/10.2133/dmpk.18.186" @default.
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