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- W2050682313 abstract "The sparing effect of reduced dose rate on the severity of the cellular radiobiological effect is interpreted in terms of a linear-quadratic dose-effect relationship which ascribes the sparing effect to the reduction in the quadratic coefficient as the dose rate is reduced. It is shown that this interpretation leads to the definition of three regions of dose rate, or irradiation time: a region of acute exposure where the quadratic coefficient maintains its maximum value, a region of protracted exposure where the quadratic coefficient decreases with decreasing dose rate and a region of chronic exposure where the quadratic coefficient is zero. The three regions are approximately defined for mammalian cells and the question is asked whether a further sparing in biological effect may be anticipated when very low dose rates were applied and the dose is accumulated over weeks or months, as is often the case in radiological protection. Experiments with Tradescantia at very low dose rates suggest that at the cellular level no further reduction in effect can be anticipated and that exposures of a few hours are long enough to define the low dose rate radiation sensitivity in mammalian systems." @default.
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- W2050682313 date "1990-06-01" @default.
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- W2050682313 title "The influence of dose rate on the dose-effect relationship" @default.
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- W2050682313 doi "https://doi.org/10.1088/0952-4746/10/2/002" @default.
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