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- W2050684194 abstract "MOTS CLES HDL-Cholesterol ; Triglycerides ; Statines ; Syndrome metabolique Statins are highly effective for lowering low-density lipoprotein (LDL) cholesterol and reaching LDL targets, but have a limited impact on triglycerides and high-density lipoprotein (HDL) cholesterol. In this issue of the journal, Laforest et al. demonstrate that high triglyceride and low HDL-cholesterol concentrations are frequent in patients treated with hypolipidaemic agents, mostly statins [1]. In this study, patients with high triglycerides and low HDL-cholesterol also had more additional risk factors, in particular diabetes and hypertension. These findings raise questions about the relevance of lipid disturbances with statin treatment in high-risk patients. Is there any point in paying attention to hypertriglyceridemia and low HDL-cholesterol in these patients? Studies in families with premature coronary disease have indeed shown that a low HDL level was the most common abnormality and was most often associated with Hypertriglyceridemia [2]. In recent statin trials in high-risk patients, the prevalence of an HDL-cholesterol concentration less than 43mg/dl was high, between 40% [3] and 60% [4]. Low HDL-cholesterol was predictive of major cardiovascular events. In the placebo arm of the Heart protection study (HPS), patients with HDL-cholesterol less than 35mg/dl had a 43% higher risk than those with HDL-cholesterol greater than 43mg/dl [4]. Treatment with simvastatin decreased this gap only moderately (33% higher risk for HDL-cholesterol less than 35mg/dl while on statin treatment). An excess of risk remained in patients with low HDL-cholesterol receiving a high dosage of statin and in" @default.
- W2050684194 created "2016-06-24" @default.
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- W2050684194 date "2009-03-01" @default.
- W2050684194 modified "2023-09-26" @default.
- W2050684194 title "High-density lipoprotein cholesterol and triglycerides in the statin era: A pending issue?" @default.
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- W2050684194 doi "https://doi.org/10.1016/j.acvd.2008.12.001" @default.
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