FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050687529> ?p ?o ?g. }

• W2050687529 endingPage "191" @default.
• W2050687529 startingPage "188" @default.
• W2050687529 abstract "Previous studies have shown that heparin antagonizes oxygen radical-mediated injury to endothelial cells, suggesting an antioxidant role of the drug. In the present investigation, the hypothesis that heparin exerts direct antioxidant effects was tested in several experimental models. We have found that 1, 3, 5, 10, 20, 40 and 80 U/mL of heparin do not scavenge Superoxide anion, hydrogen peroxide, hydroxyl radical or the stable free radical 1,1-diphenyl-2-pycrylhydrazyl. Moreover, the drug is ineffective towards iron-driven linolenic acid peroxidation, autooxidation of brain homogenate and linolenic acid peroxidation mediated by human internal mammary artery homogenate. Specific studies on the potential iron-binding-inactivating capacity of heparin prove the drug to be totally ineffective. Finally, the loss of protein sulphydryls from human plasma induced by hypoxanthine-xanthine oxidase-generated oxygen radicals is not prevented by heparin. In conclusion, heparin, even at concentrations far higher than those usually used therapeutically, has no direct antioxidant properties. Thus, other mechanisms not strictly antioxidant-type must be involved in heparin-mediated cell protection against toxic oxygen metabolites." @default.
• W2050687529 created "2016-06-24" @default.
• W2050687529 creator A5002977044 @default.
• W2050687529 creator A5003775828 @default.
• W2050687529 creator A5033196989 @default.
• W2050687529 creator A5059575023 @default.
• W2050687529 creator A5062330127 @default.
• W2050687529 creator A5067842568 @default.
• W2050687529 creator A5075907570 @default.
• W2050687529 date "1992-07-01" @default.
• W2050687529 modified "2023-09-27" @default.
• W2050687529 title "Heparin: does it act as an antioxidant in vivo?" @default.
• W2050687529 cites W1501264531 @default.
• W2050687529 cites W1541881494 @default.
• W2050687529 cites W1546482094 @default.
• W2050687529 cites W1734082729 @default.
• W2050687529 cites W1820599226 @default.
• W2050687529 cites W1825808183 @default.
• W2050687529 cites W1923166281 @default.
• W2050687529 cites W1956108131 @default.
• W2050687529 cites W1991383812 @default.
• W2050687529 cites W2006370393 @default.
• W2050687529 cites W2015990108 @default.
• W2050687529 cites W2017222748 @default.
• W2050687529 cites W2018173258 @default.
• W2050687529 cites W2024716555 @default.
• W2050687529 cites W2029218593 @default.
• W2050687529 cites W2031596649 @default.
• W2050687529 cites W2039684034 @default.
• W2050687529 cites W2053054955 @default.
• W2050687529 cites W2071218333 @default.
• W2050687529 cites W2073228236 @default.
• W2050687529 cites W2110782792 @default.
• W2050687529 cites W2131568300 @default.
• W2050687529 doi "https://doi.org/10.1016/0006-2952(92)90057-p" @default.
• W2050687529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1321628" @default.
• W2050687529 hasPublicationYear "1992" @default.
• W2050687529 type Work @default.
• W2050687529 sameAs 2050687529 @default.
• W2050687529 citedByCount "26" @default.
• W2050687529 countsByYear W20506875292014 @default.
• W2050687529 countsByYear W20506875292017 @default.
• W2050687529 countsByYear W20506875292021 @default.
• W2050687529 countsByYear W20506875292022 @default.
• W2050687529 crossrefType "journal-article" @default.
• W2050687529 hasAuthorship W2050687529A5002977044 @default.
• W2050687529 hasAuthorship W2050687529A5003775828 @default.
• W2050687529 hasAuthorship W2050687529A5033196989 @default.
• W2050687529 hasAuthorship W2050687529A5059575023 @default.
• W2050687529 hasAuthorship W2050687529A5062330127 @default.
• W2050687529 hasAuthorship W2050687529A5067842568 @default.
• W2050687529 hasAuthorship W2050687529A5075907570 @default.
• W2050687529 hasConcept C139066938 @default.
• W2050687529 hasConcept C150903083 @default.
• W2050687529 hasConcept C181199279 @default.
• W2050687529 hasConcept C185592680 @default.
• W2050687529 hasConcept C207001950 @default.
• W2050687529 hasConcept C2776573510 @default.
• W2050687529 hasConcept C2776778087 @default.
• W2050687529 hasConcept C2777557582 @default.
• W2050687529 hasConcept C2778004101 @default.
• W2050687529 hasConcept C2778102346 @default.
• W2050687529 hasConcept C2779470414 @default.
• W2050687529 hasConcept C2780795997 @default.
• W2050687529 hasConcept C2780829032 @default.
• W2050687529 hasConcept C2781116151 @default.
• W2050687529 hasConcept C533411734 @default.
• W2050687529 hasConcept C55493867 @default.
• W2050687529 hasConcept C71924100 @default.
• W2050687529 hasConcept C86803240 @default.
• W2050687529 hasConcept C98274493 @default.
• W2050687529 hasConceptScore W2050687529C139066938 @default.
• W2050687529 hasConceptScore W2050687529C150903083 @default.
• W2050687529 hasConceptScore W2050687529C181199279 @default.
• W2050687529 hasConceptScore W2050687529C185592680 @default.
• W2050687529 hasConceptScore W2050687529C207001950 @default.
• W2050687529 hasConceptScore W2050687529C2776573510 @default.
• W2050687529 hasConceptScore W2050687529C2776778087 @default.
• W2050687529 hasConceptScore W2050687529C2777557582 @default.
• W2050687529 hasConceptScore W2050687529C2778004101 @default.
• W2050687529 hasConceptScore W2050687529C2778102346 @default.
• W2050687529 hasConceptScore W2050687529C2779470414 @default.
• W2050687529 hasConceptScore W2050687529C2780795997 @default.
• W2050687529 hasConceptScore W2050687529C2780829032 @default.
• W2050687529 hasConceptScore W2050687529C2781116151 @default.
• W2050687529 hasConceptScore W2050687529C533411734 @default.
• W2050687529 hasConceptScore W2050687529C55493867 @default.
• W2050687529 hasConceptScore W2050687529C71924100 @default.
• W2050687529 hasConceptScore W2050687529C86803240 @default.
• W2050687529 hasConceptScore W2050687529C98274493 @default.
• W2050687529 hasIssue "1" @default.
• W2050687529 hasLocation W20506875291 @default.
• W2050687529 hasLocation W20506875292 @default.
• W2050687529 hasOpenAccess W2050687529 @default.
• W2050687529 hasPrimaryLocation W20506875291 @default.
• W2050687529 hasRelatedWork W1011703883 @default.
• W2050687529 hasRelatedWork W1989428232 @default.
• W2050687529 hasRelatedWork W2021390693 @default.

• next