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- W2050695096 abstract "Background: Many attempts have been made to reduce the nephrotoxicity of the anticancer agent cisplatin but the number of clinically useful modalities is very limited. Our previous experiments demonstrated that in rats methylprednisolone significantly reduces the nephrotoxicity caused by cisplatin. The present clinical study was conducted to confirm the protective effects of methylprednisolone against cisplatin nephrotoxicity. Methods: Fourteen patients with urothelial tumors were injected with cisplatin according to the methotrexate, vinblastine, adriamycin, cisplatin (MVAC) therapy. Methylprednisolone was not administered during the first course of chemotherapy to provide a control, but was given in a dose of 2000 mg 2–3 hours before cisplatin during the second course of chemotherapy (treatment period) in each patient. Urinary excretion of N-acetyl-β-D-glucosarninidase (NAG) and γ-glutamyltranspeptidase (CGTP), serum creatinine, and creatinine clearance (Ccr) were determined as indicators of the nephrotoxicity of cisplatin. Results were statistically analyzed by a paired t test to compare the nephrotoxic effects of cisplatin during the first course of chemotherapy (control period) with those during the second course of chemotherapy (treatment period). Results: Methylprednisolone did not significantly inhibit the elevation in urinary enzyme excretion or serum creatinine levels following the cisplatin injection. However, the Ccr level after cisplatin infusion in the treatment period was significantly highter than that observed in the control period. Conclusion: The protective effects of methylprednisolone against cisplatin nephrotoxicity were indicated in this prospective clinical study." @default.
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- W2050695096 date "1996-09-01" @default.
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- W2050695096 title "The Protective Effect of Methylprednisolone against Cisplatin-Induced Nephrotoxicity in Patients with Urothelial Tumors" @default.
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- W2050695096 doi "https://doi.org/10.1111/j.1442-2042.1996.tb00551.x" @default.
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