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• W2050698575 abstract "Steric barriers such as collagen I sharply limit interstitial delivery of macromolecular and nanoparticle (NP) based therapeutic agents. Collagenase-linked superparamagnetic NPs overcame these barriers and moved through in vitro extracellular matrix (ECM) at 90 μm h-1, a rate similar to invasive cells, under the influence of a magnetic field. NP migration in ECM diminished linearly over 5 days. The collagenase−NP construct overcame two of the most significant barriers to nano- and microscale therapeutics deployment: proteolytic enzyme stability was maintained during a clinically useful time frame by immobilization on the NP surface and degradation of interstitial barriers to tissue biodistribution was enabled by the conjugated microbial protease." @default.
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• W2050698575 date "2006-01-25" @default.
• W2050698575 modified "2023-09-27" @default.
• W2050698575 title "Proteolytic Surface Functionalization Enhances <i>in Vitro</i> Magnetic Nanoparticle Mobility through Extracellular Matrix" @default.
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• W2050698575 doi "https://doi.org/10.1021/nl052241g" @default.
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