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- W2050702914 abstract "Chordoma is the term applied by Ribbert (1) to those rare and invariably fatal tumors which arise from remnants of the fetal notochord. Williams (2) demonstrated the positions and limits of the notochord by reconstructions, and it is now known that remnants of that structure may be demonstrated from the spheno-occipital cartilaginous union to the sacrococcygeal region. Tissue proliferations resembling chordoma have been produced by puncturing the intervertebral discs of rabbits (1).Case reviews have been presented by Stewart and Morin (3), Coenen (4), Mabrey, (5), and others, but no instance of endocrine imbalance has been previously recorded in association with chordoma.IncidenceThe sites of occurrence of chordoma, as expected, range from the cranial and vertebral to the sacrococcygeal regions. The approximate ratio of occurrence in these regions is, cranial 5, vertebral 1.5, sacrococcygeal 9.While chordoma may occur at any age and in either sex, the sacrococcygeal type has its highest incidence in males and females between the ages of fifty and seventy. Mabrey (5) found the average age of incidence of the sphenooccipital type to be between thirty and fifty. The average age of onset of the sacrococcygeal type appears to be about fifty years in the male and forty-three years in the female, while the spheno-occipital type has its highest incidence at an average of forty years.Symptoms and DiagnosisSymptoms are usually present in the average case about two to three years before the patient seeks medical attention. The symptoms are not characteristic of chordoma but rather apply to neoplasms in the areas affected. These are, for the sacrococcygeal type, pain, tumor, and constipation with occasional occult blood and urinary disturbances. The spheno-occipital type, because of the location, may give rise to headaches, visual disturbances, or other signs of brain tumors, due to pressure, erosion, and invasion. The chief symptom of the vertebral chordoma is pain, with pressure effects involving the nerve roots." @default.
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- W2050702914 date "1937-03-01" @default.
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- W2050702914 title "Chordoma: A Case with Unusual Endocrine Findings" @default.
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