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- W2050724975 abstract "There is rightly much concern about the stability or compatibility of drugs when added to intravenous infusion fluids. There is, however, another facet of this practice which has hitherto not been given sufficient attention; i.e., the effect of such additions on the resultant sterility of the fluid. In order to determine whether there was a problem calling for further investigation, we carried out a pilot survey of 101 intravenous-fluid containers taken from the hospital ward after infusion was completed. We examined the remnants of fluid in each container for bacterial contamination. Of the 101 fluids sampled, 61 had additives incorporated on the ward, and 40 were without additives. We found that of the 61 containers with additives, 34 (55.7%) were contaminated, whereas of the 40 containers without additives, only 5 (12.5%) were contaminated. These results suggest that the incorporation of additives to infusion fluids at ward level is a procedure which may lead to bacterial contamination of the fluid. The risk would be especially high when multiple drug additives were involved. The majority of standard infusion fluids will support microbial survival and some will provide a highly nutritional medium for growth. This contamination of infusion fluids is an additional argument against such an incorporation at ward level. If there is good reason for such incorporation, then it should be done in the pharmacy department of the hospital under correct and controlled aseptic conditions." @default.
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- W2050724975 date "1973-07-01" @default.
- W2050724975 modified "2023-09-27" @default.
- W2050724975 title "DRUG ADDITIVES : A POTENTIAL SOURCE OF BACTERIAL CONTAMINATION OF INFUSION FLUIDS" @default.
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- W2050724975 doi "https://doi.org/10.1016/s0140-6736(73)93292-3" @default.
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