FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050725087> ?p ?o ?g. }

• W2050725087 endingPage "312" @default.
• W2050725087 startingPage "306" @default.
• W2050725087 abstract "Interleukin-6 (IL-6) secretion from endothelial cells (ECs) in response to mechanical stimuli plays an important role in the regenerative and inflammatory responses. The aim of this study was to determine the mechanism for the secretion of IL-6 from ECs in response to uni-axial continuous stretch. Continuous stretch induced IL-6 secretion from human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner. Reverse transcriptase-polymerase chain reaction (RT-PCR) amplification showed that the transcription of the IL-6 gene peaked 2 h after stretch. In vitro kinase assay of IκB kinase (IKKs) activity demonstrated that the activation of IKKs peaked 15 min after stretch. Two NF-κB inhibitors, pyrrolidine dithiocarbamanate (PDTC) and SN50, or antisense oligodeoxynucleotides for NF-κB p65 and p50 suppressed IL-6 mRNA expressions induced by continuous stretch. In conclusion, continuous stretch induces IL-6 secretion from ECs, most likely through sequential activation of IKKs and NF-κB." @default.
• W2050725087 created "2016-06-24" @default.
• W2050725087 creator A5013540987 @default.
• W2050725087 creator A5034145502 @default.
• W2050725087 creator A5034675205 @default.
• W2050725087 creator A5059713499 @default.
• W2050725087 creator A5064068441 @default.
• W2050725087 creator A5084473935 @default.
• W2050725087 creator A5086374531 @default.
• W2050725087 date "2003-08-01" @default.
• W2050725087 modified "2023-10-15" @default.
• W2050725087 title "Stretch-induced IL-6 secretion from endothelial cells requires NF-κB activation" @default.
• W2050725087 cites W1480466711 @default.
• W2050725087 cites W1499740591 @default.
• W2050725087 cites W1556524491 @default.
• W2050725087 cites W1786911182 @default.
• W2050725087 cites W1964905528 @default.
• W2050725087 cites W1965583590 @default.
• W2050725087 cites W1974614602 @default.
• W2050725087 cites W2002076761 @default.
• W2050725087 cites W2002657989 @default.
• W2050725087 cites W2013860138 @default.
• W2050725087 cites W2023302566 @default.
• W2050725087 cites W2024681203 @default.
• W2050725087 cites W2030403507 @default.
• W2050725087 cites W2046075244 @default.
• W2050725087 cites W2078162785 @default.
• W2050725087 cites W2081794263 @default.
• W2050725087 cites W2086371038 @default.
• W2050725087 cites W2108230556 @default.
• W2050725087 cites W2110748980 @default.
• W2050725087 cites W2116815871 @default.
• W2050725087 cites W2117774408 @default.
• W2050725087 cites W2126545660 @default.
• W2050725087 cites W2128502634 @default.
• W2050725087 cites W2150033965 @default.
• W2050725087 cites W2159026236 @default.
• W2050725087 cites W2162639891 @default.
• W2050725087 cites W2314995980 @default.
• W2050725087 cites W243618668 @default.
• W2050725087 doi "https://doi.org/10.1016/s0006-291x(03)01362-7" @default.
• W2050725087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12901869" @default.
• W2050725087 hasPublicationYear "2003" @default.
• W2050725087 type Work @default.
• W2050725087 sameAs 2050725087 @default.
• W2050725087 citedByCount "62" @default.
• W2050725087 countsByYear W20507250872012 @default.
• W2050725087 countsByYear W20507250872013 @default.
• W2050725087 countsByYear W20507250872014 @default.
• W2050725087 countsByYear W20507250872015 @default.
• W2050725087 countsByYear W20507250872016 @default.
• W2050725087 countsByYear W20507250872017 @default.
• W2050725087 countsByYear W20507250872018 @default.
• W2050725087 countsByYear W20507250872019 @default.
• W2050725087 countsByYear W20507250872020 @default.
• W2050725087 countsByYear W20507250872021 @default.
• W2050725087 countsByYear W20507250872022 @default.
• W2050725087 countsByYear W20507250872023 @default.
• W2050725087 crossrefType "journal-article" @default.
• W2050725087 hasAuthorship W2050725087A5013540987 @default.
• W2050725087 hasAuthorship W2050725087A5034145502 @default.
• W2050725087 hasAuthorship W2050725087A5034675205 @default.
• W2050725087 hasAuthorship W2050725087A5059713499 @default.
• W2050725087 hasAuthorship W2050725087A5064068441 @default.
• W2050725087 hasAuthorship W2050725087A5084473935 @default.
• W2050725087 hasAuthorship W2050725087A5086374531 @default.
• W2050725087 hasConcept C104317684 @default.
• W2050725087 hasConcept C134018914 @default.
• W2050725087 hasConcept C153911025 @default.
• W2050725087 hasConcept C156719811 @default.
• W2050725087 hasConcept C185592680 @default.
• W2050725087 hasConcept C202751555 @default.
• W2050725087 hasConcept C203014093 @default.
• W2050725087 hasConcept C2777411675 @default.
• W2050725087 hasConcept C2778690821 @default.
• W2050725087 hasConcept C49039625 @default.
• W2050725087 hasConcept C49105822 @default.
• W2050725087 hasConcept C55493867 @default.
• W2050725087 hasConcept C68324877 @default.
• W2050725087 hasConcept C86803240 @default.
• W2050725087 hasConcept C95444343 @default.
• W2050725087 hasConceptScore W2050725087C104317684 @default.
• W2050725087 hasConceptScore W2050725087C134018914 @default.
• W2050725087 hasConceptScore W2050725087C153911025 @default.
• W2050725087 hasConceptScore W2050725087C156719811 @default.
• W2050725087 hasConceptScore W2050725087C185592680 @default.
• W2050725087 hasConceptScore W2050725087C202751555 @default.
• W2050725087 hasConceptScore W2050725087C203014093 @default.
• W2050725087 hasConceptScore W2050725087C2777411675 @default.
• W2050725087 hasConceptScore W2050725087C2778690821 @default.
• W2050725087 hasConceptScore W2050725087C49039625 @default.
• W2050725087 hasConceptScore W2050725087C49105822 @default.
• W2050725087 hasConceptScore W2050725087C55493867 @default.
• W2050725087 hasConceptScore W2050725087C68324877 @default.
• W2050725087 hasConceptScore W2050725087C86803240 @default.
• W2050725087 hasConceptScore W2050725087C95444343 @default.
• W2050725087 hasIssue "2" @default.
• W2050725087 hasLocation W20507250871 @default.

• next