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• W2050727341 abstract "Overcoming drug resistance with remarkable cytotoxic activity by anthracene-9,10-dione derivatives would offer a potential therapeutic strategy. In this study, we report the synthesis and the cytotoxicity of a novel set of anthraquninones. (4-(4-Aminobenzylamino)-9,10-dioxo-9,10-dihydroanthracen-1-yl-4-methylbenzenesulfonate) (3) has excellent in vitro cytotoxicity against doxorubicin-resistant cancer cell line (IC50=0.8 μM), 20-fold higher than doxorubicin. The cytotoxic effect via G2/M arrest does not appear to be ROS." @default.
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• W2050727341 date "2013-11-01" @default.
• W2050727341 modified "2023-10-05" @default.
• W2050727341 title "Overcoming doxorubicin-resistance in the NCI/ADR-RES model cancer cell line by novel anthracene-9,10-dione derivatives" @default.
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• W2050727341 doi "https://doi.org/10.1016/j.bmcl.2013.09.004" @default.
• W2050727341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24095089" @default.
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