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- W2050731041 startingPage "931" @default.
- W2050731041 abstract "The contribution of the renal nerve to the natriuretic and diuretic responses to rat atrial natriuretic peptide (rAMP) was investigated in conscious rabbits with unilateral renal denervation. Renal nerve activity (RNA) was measured at the contralateral innervated kidney. Catheters were bilaterally implanted into the ureters. Urine samples were collected from each kidney by gravity drainage at 10-min clearance intervals. In rabbits with all baroreflexes intact, infusion of rANP at 0.3μg/(kg•min) for 30min decreased mean arterial pressure by 8±4mmHg and increased RNA by 53±13%. After sinoaortic baroreceptor denervation (SAD), hypotensive response to infusion of rANP was greater than that in intact rabbits, while RNA did not change. After SAD plus vagotomy, infusion of rANP lowered mean arterial pressure by 21±4mmHg and RNA by 19±6%. In the denervated kidney, infusion of rANP increased Na+ excretion by 16.1±4.5 from 3.5±1.0μEq/min and water excretion by 0.17±0.05 from 0.08±0.02ml/min. In the contralateral innervated kidney, infusion of rANP increased the amount of Na+ and water excretion by 4.5±3.2μq/min and 0.07±0.04ml/min, which were significantly less than those in the denervated kidney. These results indicate that infusion of rANP increases RNA, due to baroreceptor reflexes, and that this increase in RNA blunts natriuretic and diuretic action of rANP." @default.
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- W2050731041 date "1989-01-01" @default.
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- W2050731041 title "Renal nerve blunts natriuretic and diuretic response to atrial natriuretic peptide in conscious rabbits." @default.
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- W2050731041 doi "https://doi.org/10.2170/jjphysiol.39.931" @default.
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