Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050745236> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2050745236 endingPage "S200" @default.
- W2050745236 startingPage "S200" @default.
- W2050745236 abstract "Rolipram, an inhibitor of phosphodiesterase 4 (PDE4) proteins that hydrolyze cAMP, increases axonal regeneration following spinal cord injury (SCI). Recent evidence indicate that rolipram also protects against a multitude of apoptotic signals, many of which are implicated in secondary cell death post-SCI. In the present study, we used immunohistochemistry and morphometry to determine potential spinal cord targets of rolipram and to test its protective potential in rats undergoing cervical spinal cord contusive injury. We found that 3 PDE4 subtypes (PDE4A, B, D) were expressed by spinal cord oligodendrocytes. OX-42 immunopositive microglia only expressed the PDE4B subtype. Oligodendrocyte somata were quantified within the cervical ventrolateral funiculus, a white matter region critical for locomotion, at varying time points after SCI in rats receiving rolipram or vehicle treatments. We show that rolipram significantly attenuated oligodendrocyte death at 24 h post-SCI continuing through 72 h, the longest time point examined. These results demonstrate for the first time that spinal cord glial cells express PDE4 subtypes and that the PDE4 inhibitor rolipram protects oligodendrocytes from secondary cell death following contusive SCI. They also indicate that further investigations into neuroprotection and axonal regeneration with rolipram are warranted for treating SCI." @default.
- W2050745236 created "2016-06-24" @default.
- W2050745236 creator A5000701045 @default.
- W2050745236 creator A5010994708 @default.
- W2050745236 creator A5066569532 @default.
- W2050745236 creator A5084800562 @default.
- W2050745236 date "2010-08-01" @default.
- W2050745236 modified "2023-09-26" @default.
- W2050745236 title "S.24.03 Genotype-phenotype relationships for psychiatric disorders; gender effects" @default.
- W2050745236 doi "https://doi.org/10.1016/s0924-977x(10)70219-4" @default.
- W2050745236 hasPublicationYear "2010" @default.
- W2050745236 type Work @default.
- W2050745236 sameAs 2050745236 @default.
- W2050745236 citedByCount "0" @default.
- W2050745236 crossrefType "journal-article" @default.
- W2050745236 hasAuthorship W2050745236A5000701045 @default.
- W2050745236 hasAuthorship W2050745236A5010994708 @default.
- W2050745236 hasAuthorship W2050745236A5066569532 @default.
- W2050745236 hasAuthorship W2050745236A5084800562 @default.
- W2050745236 hasConcept C126322002 @default.
- W2050745236 hasConcept C126838900 @default.
- W2050745236 hasConcept C143409427 @default.
- W2050745236 hasConcept C169760540 @default.
- W2050745236 hasConcept C181199279 @default.
- W2050745236 hasConcept C25498285 @default.
- W2050745236 hasConcept C2776914184 @default.
- W2050745236 hasConcept C2776958096 @default.
- W2050745236 hasConcept C2776985911 @default.
- W2050745236 hasConcept C2778334475 @default.
- W2050745236 hasConcept C2778609137 @default.
- W2050745236 hasConcept C2779830541 @default.
- W2050745236 hasConcept C2780775167 @default.
- W2050745236 hasConcept C2781192897 @default.
- W2050745236 hasConcept C529278444 @default.
- W2050745236 hasConcept C55493867 @default.
- W2050745236 hasConcept C62826618 @default.
- W2050745236 hasConcept C71924100 @default.
- W2050745236 hasConcept C86803240 @default.
- W2050745236 hasConcept C98274493 @default.
- W2050745236 hasConceptScore W2050745236C126322002 @default.
- W2050745236 hasConceptScore W2050745236C126838900 @default.
- W2050745236 hasConceptScore W2050745236C143409427 @default.
- W2050745236 hasConceptScore W2050745236C169760540 @default.
- W2050745236 hasConceptScore W2050745236C181199279 @default.
- W2050745236 hasConceptScore W2050745236C25498285 @default.
- W2050745236 hasConceptScore W2050745236C2776914184 @default.
- W2050745236 hasConceptScore W2050745236C2776958096 @default.
- W2050745236 hasConceptScore W2050745236C2776985911 @default.
- W2050745236 hasConceptScore W2050745236C2778334475 @default.
- W2050745236 hasConceptScore W2050745236C2778609137 @default.
- W2050745236 hasConceptScore W2050745236C2779830541 @default.
- W2050745236 hasConceptScore W2050745236C2780775167 @default.
- W2050745236 hasConceptScore W2050745236C2781192897 @default.
- W2050745236 hasConceptScore W2050745236C529278444 @default.
- W2050745236 hasConceptScore W2050745236C55493867 @default.
- W2050745236 hasConceptScore W2050745236C62826618 @default.
- W2050745236 hasConceptScore W2050745236C71924100 @default.
- W2050745236 hasConceptScore W2050745236C86803240 @default.
- W2050745236 hasConceptScore W2050745236C98274493 @default.
- W2050745236 hasLocation W20507452361 @default.
- W2050745236 hasOpenAccess W2050745236 @default.
- W2050745236 hasPrimaryLocation W20507452361 @default.
- W2050745236 hasRelatedWork W2005022924 @default.
- W2050745236 hasRelatedWork W2024320394 @default.
- W2050745236 hasRelatedWork W2029742622 @default.
- W2050745236 hasRelatedWork W2042983677 @default.
- W2050745236 hasRelatedWork W2064532714 @default.
- W2050745236 hasRelatedWork W2095287240 @default.
- W2050745236 hasRelatedWork W2157566558 @default.
- W2050745236 hasRelatedWork W2741521401 @default.
- W2050745236 hasRelatedWork W3137107363 @default.
- W2050745236 hasRelatedWork W4220858185 @default.
- W2050745236 hasVolume "20" @default.
- W2050745236 isParatext "false" @default.
- W2050745236 isRetracted "false" @default.
- W2050745236 magId "2050745236" @default.
- W2050745236 workType "article" @default.