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- W2050749891 endingPage "1822" @default.
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- W2050749891 abstract "A variety of methods exist for the design or selection of antibodies and other proteins that recognize the water-soluble regions of proteins; however, companion methods for targeting transmembrane (TM) regions are not available. Here, we describe a method for the computational design of peptides that target TM helices in a sequence-specific manner. To illustrate the method, peptides were designed that specifically recognize the TM helices of two closely related integrins (α IIb β 3 and α v β 3 ) in micelles, bacterial membranes, and mammalian cells. These data show that sequence-specific recognition of helices in TM proteins can be achieved through optimization of the geometric complementarity of the target-host complex." @default.
- W2050749891 created "2016-06-24" @default.
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- W2050749891 date "2007-03-30" @default.
- W2050749891 modified "2023-10-18" @default.
- W2050749891 title "Computational Design of Peptides That Target Transmembrane Helices" @default.
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- W2050749891 doi "https://doi.org/10.1126/science.1136782" @default.
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