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- W2050762146 endingPage "96" @default.
- W2050762146 startingPage "90" @default.
- W2050762146 abstract "Activation-induced deaminase (AID) is required for three distinct reactions crucial to the diversification of the antibody repertoire; these are somatic hypermutation (SHM), class switch recombination (CSR) and gene conversion (GC). AID is a cytidine deaminase and is believed to initiate these reactions by deaminating cytidine residues in single-stranded DNA in Ig genes. This reaction has the potential to produce DNA damage in non-Ig genes and to destabilize the genome. Here, we review the current understanding of how AID is targeted and mutates Ig genes and how genome integrity is maintained during SHM, CSR and GC. Activation-induced deaminase (AID) is required for three distinct reactions crucial to the diversification of the antibody repertoire; these are somatic hypermutation (SHM), class switch recombination (CSR) and gene conversion (GC). AID is a cytidine deaminase and is believed to initiate these reactions by deaminating cytidine residues in single-stranded DNA in Ig genes. This reaction has the potential to produce DNA damage in non-Ig genes and to destabilize the genome. Here, we review the current understanding of how AID is targeted and mutates Ig genes and how genome integrity is maintained during SHM, CSR and GC." @default.
- W2050762146 created "2016-06-24" @default.
- W2050762146 creator A5003699560 @default.
- W2050762146 creator A5010713127 @default.
- W2050762146 creator A5074026984 @default.
- W2050762146 date "2005-02-01" @default.
- W2050762146 modified "2023-09-27" @default.
- W2050762146 title "Activation-induced deaminase: controversies and open questions" @default.
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- W2050762146 doi "https://doi.org/10.1016/j.it.2004.12.004" @default.
- W2050762146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15668124" @default.
- W2050762146 hasPublicationYear "2005" @default.