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• W2050765551 endingPage "e107724" @default.
• W2050765551 startingPage "e107724" @default.
• W2050765551 abstract "Understanding the signals that regulate eosinophil survival and death is critical to developing new treatments for asthma, atopy, and gastrointestinal disease. Previous studies suggest that TNF-α stimulation protects eosinophils from apoptosis, and this TNF-α-mediated protection is mediated by the upregulation of an unknown protein by NF-κB. Here, we show for the first time that eosinophils express the caspase 8-inhibitory protein c-FLIP, and c-FLIP expression is upregulated upon TNF-α stimulation. Considering that c-FLIP expression is regulated by NF-κB, we hypothesized that c-FLIP might serve as the molecular switch that converts TNFRI activation to a pro-survival signal in eosinophils. Indeed, we found that one c-FLIP isoform, c-FLIPL, is required for mouse eosinophil survival in the presence of TNF-α both in vitro and in vivo. Importantly, our results suggest c-FLIP as a potential therapeutic target for the treatment of eosinophil-mediated disease." @default.
• W2050765551 created "2016-06-24" @default.
• W2050765551 creator A5009669109 @default.
• W2050765551 creator A5023746467 @default.
• W2050765551 creator A5043784736 @default.
• W2050765551 creator A5057776121 @default.
• W2050765551 date "2014-10-21" @default.
• W2050765551 modified "2023-09-27" @default.
• W2050765551 title "c-FLIP Protects Eosinophils from TNF-α-Mediated Cell Death In Vivo" @default.
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• W2050765551 doi "https://doi.org/10.1371/journal.pone.0107724" @default.
• W2050765551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4204828" @default.
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