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- W2050774254 abstract "<i>Introduction:</i> Recent post-mortem studies of suicide victims have implicated brain-derived neurotrophic factor (BDNF) in suicide. Therefore, it was decided to examine the possible role of a gene in the regulation of BDNF activity in relation to suicidal behaviour among depressed patients. <i>Method:</i> A series of 170 depressed patients were evaluated for their history of suicide attempts and genotyped for the BDNF Val66Met polymorphism (SNP ID: rs6265). Depressed patients who had (n = 97) or had not (n = 73) attempted suicide were compared. <i>Results:</i> Depressed patients who carried the BDNF Val66Met polymorphism variant (GA + AA) appeared to show a significantly increased risk of suicidal behaviour. The risk of a suicide attempt was also significantly higher among those reporting higher levels of childhood emotional, physical and sexual abuse. Secondary analyses suggested that depression severity was a significant risk factor only in the wild-type BDNF genotype, and that the risk of suicide attempts was more predictable within the wild-type group. <i>Conclusion:</i> These preliminary data suggest that BDNF may play a role in the suicidal behaviour of depressed patients." @default.
- W2050774254 created "2016-06-24" @default.
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- W2050774254 date "2008-01-01" @default.
- W2050774254 modified "2023-10-15" @default.
- W2050774254 title "Association of Polymorphism (Val66Met) of Brain-Derived Neurotrophic Factor with Suicide Attempts in Depressed Patients" @default.
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- W2050774254 doi "https://doi.org/10.1159/000142361" @default.
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