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- W2050778891 abstract "We have investigated the role of sensory nerves in regulating airway smooth muscle function in the guinea-pig, marmoset, rabbit and man. Tissue levels of the sensory neuropeptides CGRP and substance P in the airways of the guinea-pig were significantly greater compared with the rabbit and marmoset. The relative order of tissue content was guinea-pig ⋙ rabbit = marmoset. Marmoset bronchial and tracheal preparations responded weakly to exogenously administered substance P and neurokinin A but contracted to methacholine and demonstrated atropine-sensitive cholinergic responses. In marmoset, rabbit and human airway preparations, capsaicin mediated weak contractile responses to exogenously administered capsaicin. However, high concentrations of capsaicin elicited a relaxation response that was epithelium-independent, cyclo-oxygenase-insensitive, not involving nitric oxide and not dependent on the activation of capsaicin-sensitive afferents. These results suggest that rabbit and marmoset airways respond functionally in a similar way to human airway preparations and maybe more relevant than guinea-pig airways with regard to understanding the role of sensory neuropeptides in airways." @default.
- W2050778891 created "2016-06-24" @default.
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- W2050778891 date "1998-09-01" @default.
- W2050778891 modified "2023-10-16" @default.
- W2050778891 title "A comparison of sensory nerve function in human, guinea-pig, rabbit and marmoset airways" @default.
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- W2050778891 doi "https://doi.org/10.1016/s0024-3205(98)00432-9" @default.
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