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- W2050782913 abstract "Measurement of prostate-specific antigen (PSA) has profoundly affected virtually all clinical aspects of prostate cancer. A sharp increase in both the incidence of age-adjusted prostate cancer (about 100 percent) and the proportion of patients with early stages of the disease at the time of diagnosis (stage migration) has coincided with the advent of widespread PSA testing.13 Moreover, there have been substantial shifts toward the use of radical prostatectomy in younger men and men with lower pretreatment PSA levels and a rising incidence of nonpalpable lesions (tumor [T] stage 1c).3 Currently, less than 10 percent of men have distant metastases . . ." @default.
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- W2050782913 date "2004-07-08" @default.
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- W2050782913 title "Progress toward Identifying Aggressive Prostate Cancer" @default.
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- W2050782913 doi "https://doi.org/10.1056/nejme048119" @default.
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