FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050785959> ?p ?o ?g. }

• W2050785959 endingPage "408" @default.
• W2050785959 startingPage "402" @default.
• W2050785959 abstract "Extracellularly added P 1 ,P 3 ‐di(adenosine‐5′) triphosphate (Ap 3 A), P 1 ,P 4 ‐di(adenosine‐5′) tetraphosphate (Ap 4 A), ATP, ADP, AMP and adenosine are growth inhibitory for rat C6 glioma cells. Analysis of nucleotide hydrolysis and the use of nucleotidase inhibitors demonstrated that the latter inhibition is due to hydrolysis of the nucleotides to adenosine. Agonists of the P2Y AC − ‐receptor enhance the growth of C6 cells if their hydrolysis to adenosine is inhibited by pyridoxalphosphate‐6‐azophenyl‐2′,4′‐disulfonic acid (PPADS). In these conditions, the potency to stimulate cell growth parallels the ranking of the receptor agonists, i.e. 2‐methylthioadenosine‐5′‐diphosphate (2MeSADP)>Ap 3 A>Ap 4 A. ATP and ADP are still hydrolysed in the presence of PPADS and have no proliferative effect on C6 cells. The enhanced growth is due to a P2Y AC − ‐receptor‐mediated activation of p42/44 mitogen‐activated protein kinase (MAPK) as shown by immunoblotting and protein kinase assays for active MAPK and the use of the MAPK/extracellular signal‐regulated kinase kinase (MEK) inhibitor PD98059. The UTP‐induced enhancement of the growth of C6 cells is due to activation of MAPK by a PPADS sensitive nucleotide receptor. In conclusion, the effect of nucleotides on the growth of C6 cells is determined by ecto‐nucleotidases and by activation of nucleotide receptors. Hydrolysis of nucleotides to adenosine induces growth inhibition while inhibition of the hydrolysis of agonists of the P2Y AC − ‐receptor enhances cell growth by activation of MAPK. British Journal of Pharmacology (2001) 134 , 402–408; doi: 10.1038/sj.bjp.0704271" @default.
• W2050785959 created "2016-06-24" @default.
• W2050785959 creator A5002261141 @default.
• W2050785959 creator A5026315273 @default.
• W2050785959 creator A5034377203 @default.
• W2050785959 creator A5068237560 @default.
• W2050785959 creator A5085066656 @default.
• W2050785959 date "2001-09-01" @default.
• W2050785959 modified "2023-10-13" @default.
• W2050785959 title "P2Y_AC⁻‐receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen‐activated protein kinase" @default.
• W2050785959 cites W1491762339 @default.
• W2050785959 cites W1491999047 @default.
• W2050785959 cites W1518337415 @default.
• W2050785959 cites W1607009526 @default.
• W2050785959 cites W1608256683 @default.
• W2050785959 cites W1786370853 @default.
• W2050785959 cites W1877982959 @default.
• W2050785959 cites W1886164324 @default.
• W2050785959 cites W1934031549 @default.
• W2050785959 cites W1967714236 @default.
• W2050785959 cites W1969761928 @default.
• W2050785959 cites W1976454863 @default.
• W2050785959 cites W1977677084 @default.
• W2050785959 cites W1980927246 @default.
• W2050785959 cites W1981183509 @default.
• W2050785959 cites W1986153986 @default.
• W2050785959 cites W2001052264 @default.
• W2050785959 cites W2003497280 @default.
• W2050785959 cites W2003618420 @default.
• W2050785959 cites W2019613460 @default.
• W2050785959 cites W2022593436 @default.
• W2050785959 cites W2026142963 @default.
• W2050785959 cites W2048135877 @default.
• W2050785959 cites W2048488100 @default.
• W2050785959 cites W2052530663 @default.
• W2050785959 cites W2056358535 @default.
• W2050785959 cites W2059703919 @default.
• W2050785959 cites W2060900719 @default.
• W2050785959 cites W2069004519 @default.
• W2050785959 cites W2072254379 @default.
• W2050785959 cites W2075524088 @default.
• W2050785959 cites W2081225018 @default.
• W2050785959 cites W2095066407 @default.
• W2050785959 cites W2117761238 @default.
• W2050785959 cites W2140147190 @default.
• W2050785959 cites W2148091009 @default.
• W2050785959 cites W2166736827 @default.
• W2050785959 cites W2339087061 @default.
• W2050785959 cites W2400412633 @default.
• W2050785959 doi "https://doi.org/10.1038/sj.bjp.0704271" @default.
• W2050785959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572964" @default.
• W2050785959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11564659" @default.
• W2050785959 hasPublicationYear "2001" @default.
• W2050785959 type Work @default.
• W2050785959 sameAs 2050785959 @default.
• W2050785959 citedByCount "31" @default.
• W2050785959 countsByYear W20507859592012 @default.
• W2050785959 countsByYear W20507859592013 @default.
• W2050785959 countsByYear W20507859592017 @default.
• W2050785959 countsByYear W20507859592020 @default.
• W2050785959 crossrefType "journal-article" @default.
• W2050785959 hasAuthorship W2050785959A5002261141 @default.
• W2050785959 hasAuthorship W2050785959A5026315273 @default.
• W2050785959 hasAuthorship W2050785959A5034377203 @default.
• W2050785959 hasAuthorship W2050785959A5068237560 @default.
• W2050785959 hasAuthorship W2050785959A5085066656 @default.
• W2050785959 hasBestOaLocation W20507859591 @default.
• W2050785959 hasConcept C153911025 @default.
• W2050785959 hasConcept C160225129 @default.
• W2050785959 hasConcept C16587737 @default.
• W2050785959 hasConcept C170493617 @default.
• W2050785959 hasConcept C184235292 @default.
• W2050785959 hasConcept C185592680 @default.
• W2050785959 hasConcept C2776991684 @default.
• W2050785959 hasConcept C2778938600 @default.
• W2050785959 hasConcept C2780019924 @default.
• W2050785959 hasConcept C2780410667 @default.
• W2050785959 hasConcept C55493867 @default.
• W2050785959 hasConcept C57074206 @default.
• W2050785959 hasConcept C57306754 @default.
• W2050785959 hasConcept C67907053 @default.
• W2050785959 hasConcept C86803240 @default.
• W2050785959 hasConcept C97029542 @default.
• W2050785959 hasConceptScore W2050785959C153911025 @default.
• W2050785959 hasConceptScore W2050785959C160225129 @default.
• W2050785959 hasConceptScore W2050785959C16587737 @default.
• W2050785959 hasConceptScore W2050785959C170493617 @default.
• W2050785959 hasConceptScore W2050785959C184235292 @default.
• W2050785959 hasConceptScore W2050785959C185592680 @default.
• W2050785959 hasConceptScore W2050785959C2776991684 @default.
• W2050785959 hasConceptScore W2050785959C2778938600 @default.
• W2050785959 hasConceptScore W2050785959C2780019924 @default.
• W2050785959 hasConceptScore W2050785959C2780410667 @default.
• W2050785959 hasConceptScore W2050785959C55493867 @default.
• W2050785959 hasConceptScore W2050785959C57074206 @default.
• W2050785959 hasConceptScore W2050785959C57306754 @default.
• W2050785959 hasConceptScore W2050785959C67907053 @default.
• W2050785959 hasConceptScore W2050785959C86803240 @default.

• next