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• W2050786978 abstract "While highly active anti-retroviral therapy (HAART) has improved survival of HIV-infected patients, there is increasing liver disease and progressive Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) related liver disease.To study the liver function tests (LFT) and HBV and HCV co-infection in HIV-infected patients.All HIV-positive patients presenting to a tertiary level hospital from April 2009 to April 2011 were evaluated. Baseline LFT, CD4/CD8 counts, ultrasound abdomen, HBsAg, IgG anti-HBc, HBVDNA, Anti-HCV and HCVRNA were done in all patients. LFT was repeated monthly or more frequently with anti-tubercular therapy (ATT)/HAART.Abnormal LFT were seen in 143/320 (44.6%) HIV-infected patients (n = 320; M-282, F-38; mean age-35.4 ± 7.3 years). Baseline LFT was abnormal in 48 (15%) [hepatotropic viruses-19, alcohol-24, NAFLD-1, disseminated TB-1, idiopathic-03). Subsequent LFT derangement developed in 95/272 (34.9%). In the majority, the LFT abnormality was mild (119/143–83.2%) and multi-factorial [HAART 132 (76.4%), alcohol 69 (48.2%), ATT 31 (21.7%), HBV 16 (11.2%), HCV 15 (10.4%)]. Using multivariate analysis, abnormal LFT were associated with HAART (OR, 5.92; 95%CI, 2.83–12.37), ATT (OR, 2.06; 95%CI, 1.06–3.99) or HCV infection (OR, 2.54; 95%CI, 1.03–6.26). Significant hepatotoxicity requiring drug modification was seen in only 7 cases.HBV, HCV and HBV + HCV co-infection were seen in 37 (11.6%), 28 (8.8%) and 2 (0.6%) respectively. Occult co-infections were rare [HBV-1 (0.3%); HCV-3 (0.9%)].While LFT abnormalities in HIV are common, they are usually mild and multifactorial. HBV and HCV co-infections were seen in 11.6% and 8.8%, respectively. Occult HBV and HCV infections were rare." @default.
• W2050786978 created "2016-06-24" @default.
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• W2050786978 date "2001-11-01" @default.
• W2050786978 modified "2023-10-14" @default.
• W2050786978 title "TREATMENT OF HEPATITIS C VIRUS AND HIV CO-INFECTIONS" @default.
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• W2050786978 doi "https://doi.org/10.1016/s1089-3261(05)70208-7" @default.
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• W2050786978 hasPublicationYear "2001" @default.
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