FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050793903> ?p ?o ?g. }

• W2050793903 endingPage "1228" @default.
• W2050793903 startingPage "1220" @default.
• W2050793903 abstract "Transplantation of T cell-depleted BM (TDBM) under mild conditioning, associated with minimal toxicity and reduced risk of GVHD, offers an attractive therapeutic option for patients with nonmalignant hematologic disorders and can mediate immune tolerance to subsequent organ transplantation. However, overcoming TDBM rejection after reduced conditioning remains a challenge. Here, we address this barrier using donorderived central memory CD8(+) T cells (Tcms), directed against third-party antigens. Our results show that fully allogeneic or (hostXdonor)F1-Tcm, support donor chimerism (> 6 months) in sublethally irradiated (5.5Gy) mice, without GVHD symptoms. Chimerism under yet lower irradiation (4.5Gy) was achieved by combining Tcm with short-term administration of low-dose Rapamycin. Importantly, this chimerism resulted in successful donor skin acceptance, whereas third-party skin was rejected. Tracking of host anti-donor T cells (HADTCs), that mediate TDBMT rejection, in a novel bioluminescence-imaging model revealed that Tcms both induce accumulation and eradicate HADTCs in the LNs,concomitant with their elimination from other organs, including the BM. Further analysis with 2-photon microcopy revealed that Tcms form conjugates with HADTCs, resulting in decelerated and confined movement of HADTCs within the LNs in an antigen-specific manner. Thus, anti-third-party Tcms support TDBMT engraftment under reduced-conditioning through lymph-node sequestration and deletion of HADTCs, offering a novel and potentially safe approach for attaining stable hematopoietic chimerism." @default.
• W2050793903 created "2016-06-24" @default.
• W2050793903 creator A5005492422 @default.
• W2050793903 creator A5006820395 @default.
• W2050793903 creator A5009514861 @default.
• W2050793903 creator A5014417840 @default.
• W2050793903 creator A5035602223 @default.
• W2050793903 creator A5046584051 @default.
• W2050793903 creator A5051357157 @default.
• W2050793903 creator A5053819853 @default.
• W2050793903 creator A5068965669 @default.
• W2050793903 creator A5069434242 @default.
• W2050793903 creator A5073973652 @default.
• W2050793903 creator A5075140332 @default.
• W2050793903 creator A5076794941 @default.
• W2050793903 creator A5077496405 @default.
• W2050793903 creator A5084190654 @default.
• W2050793903 date "2013-02-14" @default.
• W2050793903 modified "2023-10-12" @default.
• W2050793903 title "Murine anti–third-party central-memory CD8+ T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells" @default.
• W2050793903 cites W1522059631 @default.
• W2050793903 cites W1647115901 @default.
• W2050793903 cites W1653373310 @default.
• W2050793903 cites W1969756786 @default.
• W2050793903 cites W1975440932 @default.
• W2050793903 cites W1983416388 @default.
• W2050793903 cites W1984921956 @default.
• W2050793903 cites W1990458269 @default.
• W2050793903 cites W1991458726 @default.
• W2050793903 cites W2001890567 @default.
• W2050793903 cites W2007766732 @default.
• W2050793903 cites W2009052320 @default.
• W2050793903 cites W2013239271 @default.
• W2050793903 cites W2013306932 @default.
• W2050793903 cites W2017146999 @default.
• W2050793903 cites W2022664029 @default.
• W2050793903 cites W2024957425 @default.
• W2050793903 cites W2025003170 @default.
• W2050793903 cites W2027434623 @default.
• W2050793903 cites W2029392446 @default.
• W2050793903 cites W2036276239 @default.
• W2050793903 cites W2038101608 @default.
• W2050793903 cites W2053677929 @default.
• W2050793903 cites W2057353879 @default.
• W2050793903 cites W2077884399 @default.
• W2050793903 cites W2080505913 @default.
• W2050793903 cites W2093107492 @default.
• W2050793903 cites W2101099764 @default.
• W2050793903 cites W2104013211 @default.
• W2050793903 cites W2106238650 @default.
• W2050793903 cites W2110636000 @default.
• W2050793903 cites W2112552541 @default.
• W2050793903 cites W2121964181 @default.
• W2050793903 cites W2127532535 @default.
• W2050793903 cites W2137051639 @default.
• W2050793903 cites W2142621481 @default.
• W2050793903 cites W2153979851 @default.
• W2050793903 cites W2155521069 @default.
• W2050793903 cites W2159307350 @default.
• W2050793903 cites W2164035061 @default.
• W2050793903 cites W2168822664 @default.
• W2050793903 cites W2409535840 @default.
• W2050793903 cites W4242335840 @default.
• W2050793903 cites W4242872472 @default.
• W2050793903 doi "https://doi.org/10.1182/blood-2012-07-441493" @default.
• W2050793903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4467899" @default.
• W2050793903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23223359" @default.
• W2050793903 hasPublicationYear "2013" @default.
• W2050793903 type Work @default.
• W2050793903 sameAs 2050793903 @default.
• W2050793903 citedByCount "21" @default.
• W2050793903 countsByYear W20507939032013 @default.
• W2050793903 countsByYear W20507939032014 @default.
• W2050793903 countsByYear W20507939032015 @default.
• W2050793903 countsByYear W20507939032017 @default.
• W2050793903 countsByYear W20507939032018 @default.
• W2050793903 countsByYear W20507939032019 @default.
• W2050793903 countsByYear W20507939032021 @default.
• W2050793903 countsByYear W20507939032022 @default.
• W2050793903 countsByYear W20507939032023 @default.
• W2050793903 crossrefType "journal-article" @default.
• W2050793903 hasAuthorship W2050793903A5005492422 @default.
• W2050793903 hasAuthorship W2050793903A5006820395 @default.
• W2050793903 hasAuthorship W2050793903A5009514861 @default.
• W2050793903 hasAuthorship W2050793903A5014417840 @default.
• W2050793903 hasAuthorship W2050793903A5035602223 @default.
• W2050793903 hasAuthorship W2050793903A5046584051 @default.
• W2050793903 hasAuthorship W2050793903A5051357157 @default.
• W2050793903 hasAuthorship W2050793903A5053819853 @default.
• W2050793903 hasAuthorship W2050793903A5068965669 @default.
• W2050793903 hasAuthorship W2050793903A5069434242 @default.
• W2050793903 hasAuthorship W2050793903A5073973652 @default.
• W2050793903 hasAuthorship W2050793903A5075140332 @default.
• W2050793903 hasAuthorship W2050793903A5076794941 @default.
• W2050793903 hasAuthorship W2050793903A5077496405 @default.
• W2050793903 hasAuthorship W2050793903A5084190654 @default.
• W2050793903 hasBestOaLocation W20507939031 @default.
• W2050793903 hasConcept C109159458 @default.

• next