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- W2050794756 abstract "The role of β-adrenergic and muscarinic cholinergic systems on maximal treadmill exercise performance and systemic O2 transport during hypoxic exercise (PiO2∼70 Torr) was studied in rats acclimatized to hypobaric hypoxia (PiO2∼70 Torr for 3 weeks, A rats) and in non-acclimatized littermates (NA rats). Untreated A rats had lower resting (fh) and maximal heart rate (fhmax) and cardiac output (Q̇), and higher maximal O2 uptake (V̇O2max) than NA. The only effect of cholinergic receptor blockade with atropine (Atp) was an increase in pre-exercise fh to comparable levels in A and in NA. β1-adrenergic receptor blockade with atenolol (Aten) lowered pre-exercise fh and (fhmax) to comparable values in A and in NA rats. However, since both pre-exercise fh and fhmax were lower in untreated A, the effect of Aten was relatively smaller in A. Aten reduced maximal exercise cardiac output (Q̇max) in NA; however, tissue O2 extraction increased such that V̇O2max was not affected. Aten did not influence Q̇max or any other parameter of systemic O2 transport in A. In conclusion the increased cholinergic tone may be responsible for the lower resting fh but not the lower fhmax of A; the integrity of the β-adrenergic system is not necessary to attain V̇O2max in hypoxia either in A or in NA; the decreased response to β-adrenergic stimulation in A limits the efficacy of this system on the mechanisms of systemic O2 transport and reduces the effect of its blockade on these mechanisms." @default.
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- W2050794756 title "Role of β-adrenergic and cholinergic systems in acclimatization to hypoxia in the rat" @default.
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- W2050794756 doi "https://doi.org/10.1016/s0034-5687(96)02502-9" @default.
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