Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050796670> ?p ?o ?g. }
- W2050796670 endingPage "162" @default.
- W2050796670 startingPage "153" @default.
- W2050796670 abstract "The trend towards the use of peptides and subunit proteins in modern vaccine design has necessitated the use of immunological adjuvants to achieve effective immunity. Aluminium hydroxide, a component of the diphtheria, tetanus and hepatitis B vaccines, was first described as an adjuvant over 60 years ago and is the only adjuvant currently approved for use in humans. It is also a common component of many veterinary vaccines. While this adjuvant is effective at enhancing antibody titres to antigens, the effectiveness of aluminium hydroxide is limited due to its inability to promote cell mediated immunity. Freund's Complete Adjuvant (FCA) has been used experimentally and does stimulate cellular immunity, but is unsuitable for human and veterinary use as it promotes, amongst other toxic side effects, local inflammation and granuloma formation at the site of injection. Thus, in recent years there has been a great deal of interest in developing novel, cheap, effective and safe adjuvants which stimulate cellular, as well as humoral immunity to be used with medical and veterinary vaccines. In addition, the recent unravelling of numerous immunological pathways has facilitated the rational development of new adjuvants and allowed a better understanding of the modes of action of traditional adjuvants." @default.
- W2050796670 created "2016-06-24" @default.
- W2050796670 creator A5020934619 @default.
- W2050796670 creator A5078262379 @default.
- W2050796670 date "1995-06-01" @default.
- W2050796670 modified "2023-10-17" @default.
- W2050796670 title "Adjuvants and their modes of action" @default.
- W2050796670 cites W1502243809 @default.
- W2050796670 cites W1506565605 @default.
- W2050796670 cites W1509443850 @default.
- W2050796670 cites W1522861336 @default.
- W2050796670 cites W1527697882 @default.
- W2050796670 cites W1534239092 @default.
- W2050796670 cites W1556167776 @default.
- W2050796670 cites W1576684487 @default.
- W2050796670 cites W1578796359 @default.
- W2050796670 cites W1583594664 @default.
- W2050796670 cites W1586271020 @default.
- W2050796670 cites W1614788312 @default.
- W2050796670 cites W1634158134 @default.
- W2050796670 cites W1661244319 @default.
- W2050796670 cites W1748221817 @default.
- W2050796670 cites W1766661391 @default.
- W2050796670 cites W1864939229 @default.
- W2050796670 cites W1877627173 @default.
- W2050796670 cites W1917559826 @default.
- W2050796670 cites W1919666902 @default.
- W2050796670 cites W1921807922 @default.
- W2050796670 cites W1922307675 @default.
- W2050796670 cites W1963895695 @default.
- W2050796670 cites W1964114224 @default.
- W2050796670 cites W1966064095 @default.
- W2050796670 cites W1966842062 @default.
- W2050796670 cites W1967780364 @default.
- W2050796670 cites W1971659604 @default.
- W2050796670 cites W1972996100 @default.
- W2050796670 cites W1989729670 @default.
- W2050796670 cites W1991556375 @default.
- W2050796670 cites W1992709455 @default.
- W2050796670 cites W1996693750 @default.
- W2050796670 cites W1998346656 @default.
- W2050796670 cites W2000953149 @default.
- W2050796670 cites W2004694104 @default.
- W2050796670 cites W2005322729 @default.
- W2050796670 cites W2005905661 @default.
- W2050796670 cites W2009887707 @default.
- W2050796670 cites W2015910305 @default.
- W2050796670 cites W2024606709 @default.
- W2050796670 cites W2025372248 @default.
- W2050796670 cites W2025680525 @default.
- W2050796670 cites W2031030189 @default.
- W2050796670 cites W2034320715 @default.
- W2050796670 cites W2037223418 @default.
- W2050796670 cites W2061517625 @default.
- W2050796670 cites W2062058322 @default.
- W2050796670 cites W2062913119 @default.
- W2050796670 cites W2068552731 @default.
- W2050796670 cites W2070101126 @default.
- W2050796670 cites W2074144920 @default.
- W2050796670 cites W2080959072 @default.
- W2050796670 cites W2084990572 @default.
- W2050796670 cites W2091232024 @default.
- W2050796670 cites W2093882934 @default.
- W2050796670 cites W2095351296 @default.
- W2050796670 cites W2107462139 @default.
- W2050796670 cites W2112969654 @default.
- W2050796670 cites W2125841464 @default.
- W2050796670 cites W2127260322 @default.
- W2050796670 cites W2140301468 @default.
- W2050796670 cites W2144760559 @default.
- W2050796670 cites W2146786881 @default.
- W2050796670 cites W2150695445 @default.
- W2050796670 cites W2153131265 @default.
- W2050796670 cites W2166833626 @default.
- W2050796670 cites W2172383460 @default.
- W2050796670 cites W2326728657 @default.
- W2050796670 cites W2417553549 @default.
- W2050796670 cites W3025036998 @default.
- W2050796670 cites W4239022768 @default.
- W2050796670 cites W4244506835 @default.
- W2050796670 cites W4313316252 @default.
- W2050796670 cites W46785062 @default.
- W2050796670 doi "https://doi.org/10.1016/0301-6226(95)00016-e" @default.
- W2050796670 hasPublicationYear "1995" @default.
- W2050796670 type Work @default.
- W2050796670 sameAs 2050796670 @default.
- W2050796670 citedByCount "11" @default.
- W2050796670 countsByYear W20507966702013 @default.
- W2050796670 countsByYear W20507966702018 @default.
- W2050796670 crossrefType "journal-article" @default.
- W2050796670 hasAuthorship W2050796670A5020934619 @default.
- W2050796670 hasAuthorship W2050796670A5078262379 @default.
- W2050796670 hasConcept C121332964 @default.
- W2050796670 hasConcept C185592680 @default.
- W2050796670 hasConcept C2780791683 @default.
- W2050796670 hasConcept C41008148 @default.
- W2050796670 hasConcept C62520636 @default.
- W2050796670 hasConcept C70721500 @default.