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W2050797748 abstract "The effects of microiontophoretic ejection of tizanidine were compared with those of adrenoceptor agonists on responses of single laminae IV and V neurones to noxious and innocuous cutaneous stimuli. Tizanidine, noradrenaline and clonidine depressed neuronal responses to noxious but not innocuous stimuli. Spontaneous activity was also depressed by these three substances. By contrast, β- and α1-adrenoceptor agonists had no consistent effect on neuronal responses to cutaneous stimuli. The selective actions of tizanidine, noradrenaline and clonidine were reversibly antagonized by the α2-adrenoceptor antagonist RX781094 but not by WB4101 (α1 antagonist). The binding of an α2-adrenoceptor ligand to rat brain membranes was preferentially displaced by tizanidine. These results indicate an interaction of tizanidine with central α2-adrenoceptors." @default.
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W2050797748 date "1984-07-01" @default.
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W2050797748 title "Tizanidine (DS103-282), a centrally acting muscle relaxant, selectively depresses excitation of feline dorsal horn neurones to noxious peripheral stimuli by an action at α2-adrenoceptors" @default.
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W2050797748 doi "https://doi.org/10.1016/0304-3940(84)90019-3" @default.
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