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- W2050804913 abstract "This study describes the localization of progesterone receptors (PR) in the bovine ovary. Ovaries were obtained from 11 non-pregnant and two pregnant cows. Progesterone receptors were visualized by immunohistochemistry on paraffin sections. Nuclear staining for PR was observed in cells of the follicles, corpora lutea, theca layers, surface epithelium, tunica albuginea, and in superficial and deep stroma cells. No staining was noticed in apoptotic bodies of atretic follicles. Expression of PR in follicle cells indicates an intrafollicular role of progesterone. The higher expression in thecal cells compared with follicle cells indicates that thecal cells mediate some effects of progesterone on the follicular development. Superficial stroma cells showing high expression might have a similar influence on primordial and primary follicles. In general, luteal cells had a lower expression than follicle cells, which may be explained by the down-regulatory effect of locally produced progesterone. The lower expression in luteal cells during pregnancy can be due to the longer life span of this corpus luteum and concomitant degeneration of its PR. The high and rather constant expression of PR in cells of the surface epithelium remains to be elucidated." @default.
- W2050804913 created "2016-06-24" @default.
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- W2050804913 date "2002-06-01" @default.
- W2050804913 modified "2023-09-26" @default.
- W2050804913 title "Cell-specific Distribution of Progesterone Receptors in the Bovine Ovary" @default.
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- W2050804913 doi "https://doi.org/10.1046/j.1439-0531.2002.00357.x" @default.
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