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• W2050813360 abstract "In the present work, a new particulate controlled release system was prepared, by coating alginate-g-PCL/Ca(2+) beads with chitosan. The swelling behaviour and controlled release of a poorly water-soluble drug (theophylline) model were studied in media of varying pH, by simulating human fluids at 37 degrees C. In a simulated gastric fluid (SGF, pH 1.2), coated beads presented weak swelling (8-22%) and weak release rates (24-32% within 120min), and were able to protect the drug from this harsh environment. In a simulated intestinal fluid (SIF, pH 6.8), the swelling rates of amphiphilic beads (before disintegration) were strongly reduced (300-1100%) comparatively with those of uncoated beads (700-1700%). This can be explained by the strong electrostatic interactions between the amino groups of chitosan and the carboxylate groups of alginate-g-PCL, leading to the formation of a protective membrane of strong polyelectrolyte complex around the beads. This outermost layer effectively promoted the stability of beads under gastro-intestinal tract conditions, while the hydrophobic interactions between theophylline and PCL grafts allowed a considerable slowing down of the drug release. It was found out that combination of the protective effect of the polyelectrolyte membrane in SIF associated with the hydrophobicity of PCL grafts allowed to release a poorly water-soluble drug, in a controlled manner, for 7h, along a simulated gastro-intestinal tract." @default.
• W2050813360 created "2016-06-24" @default.
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• W2050813360 date "2010-08-01" @default.
• W2050813360 modified "2023-10-17" @default.
• W2050813360 title "Effect of chitosan coating on the swelling and controlled release of a poorly water-soluble drug from an amphiphilic and pH-sensitive hydrogel" @default.
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• W2050813360 doi "https://doi.org/10.1016/j.ijbiomac.2010.05.011" @default.
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