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- W2050818051 abstract "The aim of this study was to develop a simple, rapid and sensitive assay of nicotine in plasma for automated gas chromatographic–mass spectrometric analysis. Biological samples were extracted using pre-packed Extrelut-1 columns with 5 ml of ethyl acetate. Quantitative analysis was done using deuterium-labelled nicotine as internal standard. The limit of quantitation was 0.5 ng in 1-ml plasma samples. Precision was ranging from 13.3% to 1.64% (R.S.D.) depending on the concentration, while the deviation was 4.16%. This method has been used for determination of nicotine bioavailability from new, low-dosage, nicotine chewing gum strips." @default.
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- W2050818051 date "1998-04-01" @default.
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- W2050818051 title "Rapid solid-phase extraction method for automated gas chromatographic–mass spectrometric determination of nicotine in plasma" @default.
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- W2050818051 doi "https://doi.org/10.1016/s0378-4347(97)00579-3" @default.
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