FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050820940> ?p ?o ?g. }

• W2050820940 endingPage "1054" @default.
• W2050820940 startingPage "1046" @default.
• W2050820940 abstract "The present study analyzed the potential antinociceptive effect of the antimigraine drugs sumatriptan, dihydroergotamine or methysergide in rats submitted to the formalin test. Moreover, by using selective antagonists, the role of 5-HT1B/1D serotonergic receptors was investigated in the antinociception induced by these antimigraine drugs. The formalin test was used to assess the nociceptive activity. Overt pain-like behavior (flinching, 1 h) and evoked nociception (long-lasting secondary mechanical allodynia and hyperalgesia, 6 days) were determined in the same rat. Ipsilateral, but not contralateral, pre-treatment (in μg/paw) with sumatriptan (10–300), methysergide (1–30) or dihydroergotamine (1–30) significantly prevented flinching behavior (at 1 h) as well as secondary allodynia and hyperalgesia (at day 6) induced by formalin. Interestingly, the antinociceptive (flinching), antiallodynic and antihyperalgesic effects of sumatriptan were completely prevented by peripheral pre-treatment with selective antagonists at the 5-HT1B (SB 224289; 100) or 5-HT1D (BRL 15572; 100) receptors. In contrast, the acute antinociceptive effects of methysergide and dihydroergotamine were partially prevented by SB 224289 and BRL 15572. The antiallodynic and antihyperalgesic effects of both drugs were completely prevented by BRL 15572 and partially prevented by SB 224289. Given alone, SB 224289 or BRL 15572 did not modify per se the long-lasting secondary allodynia and hyperalgesia. The above findings suggest that: (i) the antimigraine drugs sumatriptan, methysergide and dihydroergotamine reduce the acute and chronic nociception induced by formalin; and (ii) this antinociceptive effect results from activation of peripheral 5-HT1B/1D serotonergic receptors." @default.
• W2050820940 created "2016-06-24" @default.
• W2050820940 creator A5026439229 @default.
• W2050820940 creator A5027499324 @default.
• W2050820940 creator A5063971484 @default.
• W2050820940 creator A5091853325 @default.
• W2050820940 creator A5060950931 @default.
• W2050820940 date "2013-06-01" @default.
• W2050820940 modified "2023-10-09" @default.
• W2050820940 title "Role of 5-HT1B/1D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats" @default.
• W2050820940 cites W1557421799 @default.
• W2050820940 cites W1963777402 @default.
• W2050820940 cites W1965011560 @default.
• W2050820940 cites W1966035504 @default.
• W2050820940 cites W1969681508 @default.
• W2050820940 cites W1969909110 @default.
• W2050820940 cites W1970586570 @default.
• W2050820940 cites W1970954587 @default.
• W2050820940 cites W1978278811 @default.
• W2050820940 cites W1978515941 @default.
• W2050820940 cites W1979154579 @default.
• W2050820940 cites W1981065197 @default.
• W2050820940 cites W1986930181 @default.
• W2050820940 cites W1987223426 @default.
• W2050820940 cites W1988198771 @default.
• W2050820940 cites W2000254352 @default.
• W2050820940 cites W2001658059 @default.
• W2050820940 cites W2009166297 @default.
• W2050820940 cites W2011724047 @default.
• W2050820940 cites W2011889553 @default.
• W2050820940 cites W2012507985 @default.
• W2050820940 cites W2013102497 @default.
• W2050820940 cites W2013365370 @default.
• W2050820940 cites W2018088414 @default.
• W2050820940 cites W2019023056 @default.
• W2050820940 cites W2020402371 @default.
• W2050820940 cites W2020482390 @default.
• W2050820940 cites W2023039388 @default.
• W2050820940 cites W2023786157 @default.
• W2050820940 cites W2033001509 @default.
• W2050820940 cites W2033487516 @default.
• W2050820940 cites W2034532072 @default.
• W2050820940 cites W2034877425 @default.
• W2050820940 cites W2036062643 @default.
• W2050820940 cites W2042219896 @default.
• W2050820940 cites W2044188934 @default.
• W2050820940 cites W2063451203 @default.
• W2050820940 cites W2065191064 @default.
• W2050820940 cites W2065826282 @default.
• W2050820940 cites W2066946476 @default.
• W2050820940 cites W2071365317 @default.
• W2050820940 cites W2072054243 @default.
• W2050820940 cites W2072410863 @default.
• W2050820940 cites W2078065256 @default.
• W2050820940 cites W2083138746 @default.
• W2050820940 cites W2086967700 @default.
• W2050820940 cites W2087454739 @default.
• W2050820940 cites W2087542465 @default.
• W2050820940 cites W2089860708 @default.
• W2050820940 cites W2099217097 @default.
• W2050820940 cites W2099415738 @default.
• W2050820940 cites W2118440775 @default.
• W2050820940 cites W2124796000 @default.
• W2050820940 cites W2149994181 @default.
• W2050820940 cites W2150260145 @default.
• W2050820940 cites W2164366713 @default.
• W2050820940 cites W2166485517 @default.
• W2050820940 cites W2166683822 @default.
• W2050820940 cites W2170019750 @default.
• W2050820940 cites W2331665880 @default.
• W2050820940 cites W2440851120 @default.
• W2050820940 doi "https://doi.org/10.1016/j.lfs.2013.03.023" @default.
• W2050820940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23583574" @default.
• W2050820940 hasPublicationYear "2013" @default.
• W2050820940 type Work @default.
• W2050820940 sameAs 2050820940 @default.
• W2050820940 citedByCount "9" @default.
• W2050820940 countsByYear W20508209402014 @default.
• W2050820940 countsByYear W20508209402015 @default.
• W2050820940 countsByYear W20508209402016 @default.
• W2050820940 countsByYear W20508209402017 @default.
• W2050820940 countsByYear W20508209402019 @default.
• W2050820940 crossrefType "journal-article" @default.
• W2050820940 hasAuthorship W2050820940A5026439229 @default.
• W2050820940 hasAuthorship W2050820940A5027499324 @default.
• W2050820940 hasAuthorship W2050820940A5060950931 @default.
• W2050820940 hasAuthorship W2050820940A5063971484 @default.
• W2050820940 hasAuthorship W2050820940A5091853325 @default.
• W2050820940 hasConcept C126322002 @default.
• W2050820940 hasConcept C15490471 @default.
• W2050820940 hasConcept C170493617 @default.
• W2050820940 hasConcept C185592680 @default.
• W2050820940 hasConcept C2775864247 @default.
• W2050820940 hasConcept C2777883359 @default.
• W2050820940 hasConcept C2778541695 @default.
• W2050820940 hasConcept C2778871607 @default.
• W2050820940 hasConcept C2778938600 @default.
• W2050820940 hasConcept C2779245659 @default.

• next