FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050824478> ?p ?o ?g. }

• W2050824478 endingPage "559" @default.
• W2050824478 startingPage "545" @default.
• W2050824478 abstract "The lung offers a rich opportunity for development of therapeutic strategies focused on isozymes of protein kinase C (PKCs). PKCs are important in many cellular responses in the lung, and existing therapies for pulmonary disorders are inadequate. The lung poses unique challenges as it interfaces with air and blood, contains a pulmonary and systemic circulation, and consists of many cell types. Key structures are bronchial and pulmonary vessels, branching airways, and distal air sacs defined by alveolar walls containing capillaries and interstitial space. The cellular composition of each vessel, airway, and alveolar wall is heterogeneous. Injurious environmental stimuli signal through PKCs and cause a variety of disorders. Edema formation and pulmonary hypertension (PHTN) result from derangements in endothelial, smooth muscle (SM), and/or adventitial fibroblast cell phenotype. Asthma, chronic obstructive pulmonary disease (COPD), and lung cancer are characterized by distinctive pathological changes in airway epithelial, SM, and mucous-generating cells. Acute and chronic pneumonitis and fibrosis occur in the alveolar space and interstitium with type 2 pneumocytes and interstitial fibroblasts/myofibroblasts playing a prominent role. At each site, inflammatory, immune, and vascular progenitor cells contribute to the injury and repair process. Many strategies have been used to investigate PKCs in lung injury. Isolated organ preparations and whole animal studies are powerful approaches especially when genetically engineered mice are used. More analysis of PKC isozymes in normal and diseased human lung tissue and cells is needed to complement this work. Since opposing or counter-regulatory effects of selected PKCs in the same cell or tissue have been found, it may be desirable to target more than one PKC isozyme and potentially in different directions. Because multiple signaling pathways contribute to the key cellular responses important in lung biology, therapeutic strategies targeting PKCs may be more effective if combined with inhibitors of other pathways for additive or synergistic effect. Mechanisms that regulate PKC activity, including phosphorylation and interaction with isozyme-specific binding proteins, are also potential therapeutic targets. Key isotypes of PKC involved in lung pathophysiology are summarized and current and evolving therapeutic approaches to target them are identified." @default.
• W2050824478 created "2016-06-24" @default.
• W2050824478 creator A5002284668 @default.
• W2050824478 creator A5059343570 @default.
• W2050824478 creator A5066550619 @default.
• W2050824478 date "2007-06-01" @default.
• W2050824478 modified "2023-10-11" @default.
• W2050824478 title "Lung disease and PKCs" @default.
• W2050824478 cites W139762675 @default.
• W2050824478 cites W1490042759 @default.
• W2050824478 cites W1498711077 @default.
• W2050824478 cites W1520044475 @default.
• W2050824478 cites W1526362532 @default.
• W2050824478 cites W1567522550 @default.
• W2050824478 cites W1603862123 @default.
• W2050824478 cites W1607258414 @default.
• W2050824478 cites W1607565010 @default.
• W2050824478 cites W1767727568 @default.
• W2050824478 cites W1880254581 @default.
• W2050824478 cites W1886472157 @default.
• W2050824478 cites W1921874305 @default.
• W2050824478 cites W1966125684 @default.
• W2050824478 cites W1966265295 @default.
• W2050824478 cites W1972716853 @default.
• W2050824478 cites W1973556415 @default.
• W2050824478 cites W1979696209 @default.
• W2050824478 cites W1980905934 @default.
• W2050824478 cites W1984790811 @default.
• W2050824478 cites W1987433445 @default.
• W2050824478 cites W1987445277 @default.
• W2050824478 cites W1988050363 @default.
• W2050824478 cites W1990584310 @default.
• W2050824478 cites W1990697412 @default.
• W2050824478 cites W1992024544 @default.
• W2050824478 cites W2000708019 @default.
• W2050824478 cites W2005076455 @default.
• W2050824478 cites W2005907096 @default.
• W2050824478 cites W2009164208 @default.
• W2050824478 cites W2012978268 @default.
• W2050824478 cites W2015157179 @default.
• W2050824478 cites W2016168978 @default.
• W2050824478 cites W2020221534 @default.
• W2050824478 cites W2021911222 @default.
• W2050824478 cites W2023494473 @default.
• W2050824478 cites W2028030188 @default.
• W2050824478 cites W2029904148 @default.
• W2050824478 cites W2030592626 @default.
• W2050824478 cites W2032412341 @default.
• W2050824478 cites W2032919245 @default.
• W2050824478 cites W2033657262 @default.
• W2050824478 cites W2036229725 @default.
• W2050824478 cites W2037211853 @default.
• W2050824478 cites W2041797033 @default.
• W2050824478 cites W2041848671 @default.
• W2050824478 cites W2042594798 @default.
• W2050824478 cites W2042830060 @default.
• W2050824478 cites W2045912042 @default.
• W2050824478 cites W2046525768 @default.
• W2050824478 cites W2049157915 @default.
• W2050824478 cites W2049967046 @default.
• W2050824478 cites W2050959099 @default.
• W2050824478 cites W2054808987 @default.
• W2050824478 cites W2055252561 @default.
• W2050824478 cites W2055296003 @default.
• W2050824478 cites W2057227614 @default.
• W2050824478 cites W2058900741 @default.
• W2050824478 cites W2059224508 @default.
• W2050824478 cites W2062819777 @default.
• W2050824478 cites W2068609129 @default.
• W2050824478 cites W2070311059 @default.
• W2050824478 cites W2070601078 @default.
• W2050824478 cites W2072963392 @default.
• W2050824478 cites W2075033104 @default.
• W2050824478 cites W2080484776 @default.
• W2050824478 cites W2082473607 @default.
• W2050824478 cites W2082801302 @default.
• W2050824478 cites W2086724299 @default.
• W2050824478 cites W2089330962 @default.
• W2050824478 cites W2090133588 @default.
• W2050824478 cites W2098180530 @default.
• W2050824478 cites W2105902643 @default.
• W2050824478 cites W2106224747 @default.
• W2050824478 cites W2106898231 @default.
• W2050824478 cites W2107282732 @default.
• W2050824478 cites W2110100783 @default.
• W2050824478 cites W2120168649 @default.
• W2050824478 cites W2123669160 @default.
• W2050824478 cites W2124206700 @default.
• W2050824478 cites W2126736750 @default.
• W2050824478 cites W2127222392 @default.
• W2050824478 cites W2129742695 @default.
• W2050824478 cites W2129965949 @default.
• W2050824478 cites W2136616179 @default.
• W2050824478 cites W2139881033 @default.
• W2050824478 cites W2144821426 @default.
• W2050824478 cites W2146011900 @default.
• W2050824478 cites W2146989813 @default.
• W2050824478 cites W2147453963 @default.

• next