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• W2050829166 abstract "<h2>Abstract</h2><h3>Introduction</h3> Eicosanoids are important in bone physiology but the specific function of phopholipase enzymes has not been determined in osteoclasts. The objective of this is study was to determine the presence of cPLA₂ in human <i>in vitro</i>-differentiated osteoclasts as well as osteoclasts <i>in situ</i> from bone biopsies. <h3>Materials and methods</h3> Osteoclastogenesis, apoptosis, bone resorption and the modulation of actin cytoskeleton assays were performed on osteoclasts differentiated <i>in vitro</i>. Immunohistochemistry was done in differentiated osteoclasts as well as on bone biopsies. <h3>Results</h3> Human osteoclasts from normal, fetal, osteoarthritic, osteoporotic and Pagetic bone biopsies express cPLA₂ and stimulation with RANKL increases cPLA₂ phosphorylation <i>in vitro</i>. Inhibition of cPLA₂ increased osteoclastogenesis and decreased apoptosis but decreased the capacity of osteoclasts to generate actin rings and to resorb bone. <h3>Discussion and conclusions</h3> These results suggest that cPLA₂ modulates osteoclast functions and could be a useful target in bone diseases with hyperactivated osteoclasts." @default.
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• W2050829166 date "2014-04-01" @default.
• W2050829166 modified "2023-09-24" @default.
• W2050829166 title "Cytosolic phospholipase A2 and eicosanoids modulate life, death and function of human osteoclasts in vitro" @default.
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• W2050829166 doi "https://doi.org/10.1016/j.plefa.2013.12.009" @default.
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