Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050830900> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2050830900 endingPage "25" @default.
- W2050830900 startingPage "10" @default.
- W2050830900 abstract "Minoxidil, a vasodilating antihypertensive drug, was given orally at 10 mg/kg daily for 2 days to twelve 25- to 35-kg miniature pigs. Twelve control pigs were also studied. Minoxidil-treated pigs had tachycardia and hypotension and were killed 24 hr after the second dose. Gross examination showed diffuse hemorrhage in left atrial epicardium in all pigs, and alos in ventricular epicardium (2 of 12 pigs) and endocardium (3 of 12 pigs). Pale areas of necrosis were observed on incision of the left ventricular papillary muscles in 3 pigs. Light and electron microscopic studies showed acute vascular damage with hemorrhage in the left atrial epicardium. Affected arterioles had endothelial cell swelling and transmural and perivascular accumulations of leukocytes, edema fluid, fibrin clumps, and erythrocytes. The swollen endothelial cells had large, irregularly shaped nuclei with abundant euchromatin; mitotic figures were frequent. The cytoplasm contained numerous polysomes and cisterns of rough endoplasmic reticulum. Fibroblasts adjacent to damaged vessels had edematous cytoplasm and increased amounts of rough endoplasmic reticulum. In the affected left ventricular papillary muscles, necrotic myocytes showed contraction bands, mitochondrial matrical densities, lipid accumulation, initial lysis of I bands, and pyknotic nuclei. The lesions were judged to result from two mechanisms: (1) hemorrhagic lesions from drug-induced vascular injury centered on epicardial and subepicardial arterioles and (2) papillary muscle necrosis from ischemic injury from hypoperfusion during minoxidil-induced tachycardia and hypotension." @default.
- W2050830900 created "2016-06-24" @default.
- W2050830900 creator A5024335893 @default.
- W2050830900 creator A5044739221 @default.
- W2050830900 creator A5057479922 @default.
- W2050830900 date "1984-08-01" @default.
- W2050830900 modified "2023-10-03" @default.
- W2050830900 title "Cardiac morphologic alterations in acute minoxidil cardiotoxicity in miniature swine" @default.
- W2050830900 cites W1966627808 @default.
- W2050830900 cites W1971984162 @default.
- W2050830900 cites W1973648841 @default.
- W2050830900 cites W1983808021 @default.
- W2050830900 cites W2004726530 @default.
- W2050830900 cites W2008846282 @default.
- W2050830900 cites W2009248393 @default.
- W2050830900 cites W2020737175 @default.
- W2050830900 cites W2031370541 @default.
- W2050830900 cites W2043109035 @default.
- W2050830900 cites W2070539599 @default.
- W2050830900 cites W2083556324 @default.
- W2050830900 cites W2090019796 @default.
- W2050830900 cites W2095920228 @default.
- W2050830900 cites W2335314941 @default.
- W2050830900 cites W2408639843 @default.
- W2050830900 doi "https://doi.org/10.1016/0014-4800(84)90003-0" @default.
- W2050830900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6468630" @default.
- W2050830900 hasPublicationYear "1984" @default.
- W2050830900 type Work @default.
- W2050830900 sameAs 2050830900 @default.
- W2050830900 citedByCount "28" @default.
- W2050830900 countsByYear W20508309002012 @default.
- W2050830900 countsByYear W20508309002016 @default.
- W2050830900 countsByYear W20508309002021 @default.
- W2050830900 countsByYear W20508309002022 @default.
- W2050830900 crossrefType "journal-article" @default.
- W2050830900 hasAuthorship W2050830900A5024335893 @default.
- W2050830900 hasAuthorship W2050830900A5044739221 @default.
- W2050830900 hasAuthorship W2050830900A5057479922 @default.
- W2050830900 hasConcept C105702510 @default.
- W2050830900 hasConcept C126322002 @default.
- W2050830900 hasConcept C142724271 @default.
- W2050830900 hasConcept C158617107 @default.
- W2050830900 hasConcept C21613296 @default.
- W2050830900 hasConcept C2777274916 @default.
- W2050830900 hasConcept C2780886150 @default.
- W2050830900 hasConcept C503630168 @default.
- W2050830900 hasConcept C55493867 @default.
- W2050830900 hasConcept C71924100 @default.
- W2050830900 hasConcept C85378888 @default.
- W2050830900 hasConcept C86803240 @default.
- W2050830900 hasConceptScore W2050830900C105702510 @default.
- W2050830900 hasConceptScore W2050830900C126322002 @default.
- W2050830900 hasConceptScore W2050830900C142724271 @default.
- W2050830900 hasConceptScore W2050830900C158617107 @default.
- W2050830900 hasConceptScore W2050830900C21613296 @default.
- W2050830900 hasConceptScore W2050830900C2777274916 @default.
- W2050830900 hasConceptScore W2050830900C2780886150 @default.
- W2050830900 hasConceptScore W2050830900C503630168 @default.
- W2050830900 hasConceptScore W2050830900C55493867 @default.
- W2050830900 hasConceptScore W2050830900C71924100 @default.
- W2050830900 hasConceptScore W2050830900C85378888 @default.
- W2050830900 hasConceptScore W2050830900C86803240 @default.
- W2050830900 hasIssue "1" @default.
- W2050830900 hasLocation W20508309001 @default.
- W2050830900 hasLocation W20508309002 @default.
- W2050830900 hasOpenAccess W2050830900 @default.
- W2050830900 hasPrimaryLocation W20508309001 @default.
- W2050830900 hasRelatedWork W2056098869 @default.
- W2050830900 hasRelatedWork W2147264580 @default.
- W2050830900 hasRelatedWork W2159539719 @default.
- W2050830900 hasRelatedWork W2363723136 @default.
- W2050830900 hasRelatedWork W2465500966 @default.
- W2050830900 hasRelatedWork W2491034328 @default.
- W2050830900 hasRelatedWork W2530409983 @default.
- W2050830900 hasRelatedWork W2818380 @default.
- W2050830900 hasRelatedWork W3035935633 @default.
- W2050830900 hasRelatedWork W9090080 @default.
- W2050830900 hasVolume "41" @default.
- W2050830900 isParatext "false" @default.
- W2050830900 isRetracted "false" @default.
- W2050830900 magId "2050830900" @default.
- W2050830900 workType "article" @default.