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• W2050834494 endingPage "4430" @default.
• W2050834494 startingPage "4418" @default.
• W2050834494 abstract "FSH and LH are gonadotropins (GTH) that control all major events of gonadal function. FSH and LH signal through their cognate receptors, FSH receptor and LH/choriogonadotropin receptor, respectively, across vertebrates. Compared with the information in mammals, very little is known about these receptors in fish, especially the regulation of their expression. In female zebrafish, fshr and lhcgr exhibit significant temporal difference in expression, with fshr increasing first when the follicles are activated to enter the vitellogenic growth phase and lhcgr lagging behind. This raises an interesting question on the differential regulation of these two GTH receptors (GTHR) during folliculogenesis. Using a primary follicle cell culture, the present study demonstrated that 17β-estradiol (E2), but not testosterone, was a potent endocrine hormone that differentially regulated the expression of fshr and lhcgr. Although E2 stimulated both receptors, its effect on the steady-state level of lhcgr mRNA was much higher (&gt;8-fold up-regulation) than that of fshr (∼0.5-fold increase). E2 likely acted at the transcription level via its nuclear estrogen receptors (ERα and ERβ), because ICI 182,780 could abolish its effects. However, our evidence suggested that these receptors might be localized on the plasma membrane, because β-estradiol 6-(O-carboxy methyl)oxime:BSA could fully mimic the effects of E2. Demonstrating that E2 is likely one of the differentiating factors for the distinct expression of the two GTHR in the zebrafish ovary, this study sheds important light on the functions of the two GTH and their receptors in fish as well as the conservation and diverse aspects of GTHR regulation across vertebrates." @default.
• W2050834494 created "2016-06-24" @default.
• W2050834494 creator A5011297565 @default.
• W2050834494 creator A5020875478 @default.
• W2050834494 creator A5045597712 @default.
• W2050834494 date "2011-08-30" @default.
• W2050834494 modified "2023-10-16" @default.
• W2050834494 title "Differential Regulation of Gonadotropin Receptors (fshr and lhcgr) by Estradiol in the Zebrafish Ovary Involves Nuclear Estrogen Receptors That Are Likely Located on the Plasma Membrane" @default.
• W2050834494 cites W1566992573 @default.
• W2050834494 cites W1680105951 @default.
• W2050834494 cites W1857343796 @default.
• W2050834494 cites W1928260425 @default.
• W2050834494 cites W1966070246 @default.
• W2050834494 cites W1971406075 @default.
• W2050834494 cites W1974471530 @default.
• W2050834494 cites W1974886898 @default.
• W2050834494 cites W1979576387 @default.
• W2050834494 cites W1979862433 @default.
• W2050834494 cites W1980165114 @default.
• W2050834494 cites W1980519264 @default.
• W2050834494 cites W1982029559 @default.
• W2050834494 cites W1983616496 @default.
• W2050834494 cites W1984689888 @default.
• W2050834494 cites W1986038688 @default.
• W2050834494 cites W1990541708 @default.
• W2050834494 cites W1992013972 @default.
• W2050834494 cites W1994865784 @default.
• W2050834494 cites W1996199571 @default.
• W2050834494 cites W1997376261 @default.
• W2050834494 cites W2000632853 @default.
• W2050834494 cites W2001101267 @default.
• W2050834494 cites W2004065307 @default.
• W2050834494 cites W2006523356 @default.
• W2050834494 cites W2012139589 @default.
• W2050834494 cites W2012428547 @default.
• W2050834494 cites W2017440399 @default.
• W2050834494 cites W2021560293 @default.
• W2050834494 cites W2022226324 @default.
• W2050834494 cites W2023189063 @default.
• W2050834494 cites W2028604250 @default.
• W2050834494 cites W2032926727 @default.
• W2050834494 cites W2035736612 @default.
• W2050834494 cites W2043178059 @default.
• W2050834494 cites W2043317027 @default.
• W2050834494 cites W2052298830 @default.
• W2050834494 cites W2052636645 @default.
• W2050834494 cites W2055360062 @default.
• W2050834494 cites W2057615981 @default.
• W2050834494 cites W2058531950 @default.
• W2050834494 cites W2059468096 @default.
• W2050834494 cites W2059633680 @default.
• W2050834494 cites W2060707600 @default.
• W2050834494 cites W2062174925 @default.
• W2050834494 cites W2065123066 @default.
• W2050834494 cites W2072240610 @default.
• W2050834494 cites W2076710220 @default.
• W2050834494 cites W2083158575 @default.
• W2050834494 cites W2083694687 @default.
• W2050834494 cites W2083971838 @default.
• W2050834494 cites W2087193784 @default.
• W2050834494 cites W2095033420 @default.
• W2050834494 cites W2095179384 @default.
• W2050834494 cites W2097659429 @default.
• W2050834494 cites W2101467600 @default.
• W2050834494 cites W2103293341 @default.
• W2050834494 cites W2104795646 @default.
• W2050834494 cites W2106420898 @default.
• W2050834494 cites W2110670204 @default.
• W2050834494 cites W2110825908 @default.
• W2050834494 cites W2113443177 @default.
• W2050834494 cites W2113604200 @default.
• W2050834494 cites W2114745975 @default.
• W2050834494 cites W2119937630 @default.
• W2050834494 cites W2121542235 @default.
• W2050834494 cites W2122015809 @default.
• W2050834494 cites W2126890388 @default.
• W2050834494 cites W2127538148 @default.
• W2050834494 cites W2130472558 @default.
• W2050834494 cites W2132180344 @default.
• W2050834494 cites W2132274358 @default.
• W2050834494 cites W2132572441 @default.
• W2050834494 cites W2133344686 @default.
• W2050834494 cites W2133843070 @default.
• W2050834494 cites W2135089584 @default.
• W2050834494 cites W2136784996 @default.
• W2050834494 cites W2138112162 @default.
• W2050834494 cites W2141379557 @default.
• W2050834494 cites W2143246176 @default.
• W2050834494 cites W2143622187 @default.
• W2050834494 cites W2146513580 @default.
• W2050834494 cites W2151563936 @default.
• W2050834494 cites W2156051448 @default.
• W2050834494 cites W2158477450 @default.
• W2050834494 cites W2169495946 @default.
• W2050834494 cites W2414342047 @default.
• W2050834494 doi "https://doi.org/10.1210/en.2011-1065" @default.
• W2050834494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21878512" @default.
• W2050834494 hasPublicationYear "2011" @default.

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