FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050846265> ?p ?o ?g. }

• W2050846265 endingPage "e107392" @default.
• W2050846265 startingPage "e107392" @default.
• W2050846265 abstract "Studies with dietary supplementation of various types of fibers have shown beneficial effects on symptoms of the metabolic syndrome. Short-chain fatty acids (SCFAs), the main products of intestinal bacterial fermentation of dietary fiber, have been suggested to play a key role. Whether the concentration of SCFAs or their metabolism drives these beneficial effects is not yet clear. In this study we investigated the SCFA concentrations and in vivo host uptake fluxes in the absence or presence of the dietary fiber guar gum. C57Bl/6J mice were fed a high-fat diet supplemented with 0%, 5%, 7.5% or 10% of the fiber guar gum. To determine the effect on SCFA metabolism, 13C-labeled acetate, propionate or butyrate were infused into the cecum of mice for 6 h and the isotopic enrichment of cecal SCFAs was measured. The in vivo production, uptake and bacterial interconversion of acetate, propionate and butyrate were calculated by combining the data from the three infusion experiments in a single steady-state isotope model. Guar gum treatment decreased markers of the metabolic syndrome (body weight, adipose weight, triglycerides, glucose and insulin levels and HOMA-IR) in a dose-dependent manner. In addition, hepatic mRNA expression of genes involved in gluconeogenesis and fatty acid synthesis decreased dose-dependently by guar gum treatment. Cecal SCFA concentrations were increased compared to the control group, but no differences were observed between the different guar gum doses. Thus, no significant correlation was found between cecal SCFA concentrations and metabolic markers. In contrast, in vivo SCFA uptake fluxes by the host correlated linearly with metabolic markers. We argue that in vivo SCFA fluxes, and not concentrations, govern the protection from the metabolic syndrome by dietary fibers." @default.
• W2050846265 created "2016-06-24" @default.
• W2050846265 creator A5003115146 @default.
• W2050846265 creator A5010552977 @default.
• W2050846265 creator A5025605392 @default.
• W2050846265 creator A5045489297 @default.
• W2050846265 creator A5046047916 @default.
• W2050846265 creator A5064034989 @default.
• W2050846265 creator A5068054218 @default.
• W2050846265 creator A5074406851 @default.
• W2050846265 creator A5075308179 @default.
• W2050846265 date "2014-09-09" @default.
• W2050846265 modified "2023-09-27" @default.
• W2050846265 title "The Short-Chain Fatty Acid Uptake Fluxes by Mice on a Guar Gum Supplemented Diet Associate with Amelioration of Major Biomarkers of the Metabolic Syndrome" @default.
• W2050846265 cites W1850775144 @default.
• W2050846265 cites W1903148056 @default.
• W2050846265 cites W1934624334 @default.
• W2050846265 cites W1954014062 @default.
• W2050846265 cites W1963687571 @default.
• W2050846265 cites W1966869097 @default.
• W2050846265 cites W1969626483 @default.
• W2050846265 cites W1978819011 @default.
• W2050846265 cites W1980329543 @default.
• W2050846265 cites W1982920909 @default.
• W2050846265 cites W1989830348 @default.
• W2050846265 cites W2012490955 @default.
• W2050846265 cites W2014379712 @default.
• W2050846265 cites W2014444288 @default.
• W2050846265 cites W2023113611 @default.
• W2050846265 cites W2031776562 @default.
• W2050846265 cites W2032264680 @default.
• W2050846265 cites W2036411298 @default.
• W2050846265 cites W2042074642 @default.
• W2050846265 cites W2057039181 @default.
• W2050846265 cites W2063166926 @default.
• W2050846265 cites W2064654077 @default.
• W2050846265 cites W2074145107 @default.
• W2050846265 cites W2082578477 @default.
• W2050846265 cites W2083119809 @default.
• W2050846265 cites W2086487313 @default.
• W2050846265 cites W2100797163 @default.
• W2050846265 cites W2101209169 @default.
• W2050846265 cites W2103779951 @default.
• W2050846265 cites W2110936821 @default.
• W2050846265 cites W2111609149 @default.
• W2050846265 cites W2121006673 @default.
• W2050846265 cites W2124568381 @default.
• W2050846265 cites W2133254839 @default.
• W2050846265 cites W2133403209 @default.
• W2050846265 cites W2136500114 @default.
• W2050846265 cites W2149243422 @default.
• W2050846265 cites W2152311269 @default.
• W2050846265 cites W2153535399 @default.
• W2050846265 cites W2166328575 @default.
• W2050846265 cites W2167062509 @default.
• W2050846265 cites W4239161018 @default.
• W2050846265 doi "https://doi.org/10.1371/journal.pone.0107392" @default.
• W2050846265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4159349" @default.
• W2050846265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25203112" @default.
• W2050846265 hasPublicationYear "2014" @default.
• W2050846265 type Work @default.
• W2050846265 sameAs 2050846265 @default.
• W2050846265 citedByCount "60" @default.
• W2050846265 countsByYear W20508462652015 @default.
• W2050846265 countsByYear W20508462652016 @default.
• W2050846265 countsByYear W20508462652017 @default.
• W2050846265 countsByYear W20508462652018 @default.
• W2050846265 countsByYear W20508462652019 @default.
• W2050846265 countsByYear W20508462652020 @default.
• W2050846265 countsByYear W20508462652021 @default.
• W2050846265 countsByYear W20508462652022 @default.
• W2050846265 countsByYear W20508462652023 @default.
• W2050846265 crossrefType "journal-article" @default.
• W2050846265 hasAuthorship W2050846265A5003115146 @default.
• W2050846265 hasAuthorship W2050846265A5010552977 @default.
• W2050846265 hasAuthorship W2050846265A5025605392 @default.
• W2050846265 hasAuthorship W2050846265A5045489297 @default.
• W2050846265 hasAuthorship W2050846265A5046047916 @default.
• W2050846265 hasAuthorship W2050846265A5064034989 @default.
• W2050846265 hasAuthorship W2050846265A5068054218 @default.
• W2050846265 hasAuthorship W2050846265A5074406851 @default.
• W2050846265 hasAuthorship W2050846265A5075308179 @default.
• W2050846265 hasBestOaLocation W20508462651 @default.
• W2050846265 hasConcept C100544194 @default.
• W2050846265 hasConcept C126322002 @default.
• W2050846265 hasConcept C134018914 @default.
• W2050846265 hasConcept C150903083 @default.
• W2050846265 hasConcept C17093226 @default.
• W2050846265 hasConcept C185592680 @default.
• W2050846265 hasConcept C207001950 @default.
• W2050846265 hasConcept C2776229602 @default.
• W2050846265 hasConcept C2776551768 @default.
• W2050846265 hasConcept C2776725572 @default.
• W2050846265 hasConcept C2776979534 @default.
• W2050846265 hasConcept C2777507495 @default.
• W2050846265 hasConcept C2777866211 @default.
• W2050846265 hasConcept C2779306644 @default.
• W2050846265 hasConcept C2780014933 @default.

• next