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• W2050853893 startingPage "690" @default.
• W2050853893 abstract "1 Calmodulin (CaM) has a biphasic effect on Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR): potentiation and inhibition at low (pCa > 6.0) and high (pCa 5) Ca2+ concentrations, respectively. To characterize the mode of action of CaM, we studied the effect of CaM antagonists on the CICR in skinned muscle fibres of the rabbit. Ca2+ release was measured by microfluorometry with Fura-2. 2 A CaM antagonist, trifluoperazine (TFP), potentiated the CICR in a dose-dependent manner (10–300 μm) at pCa 6, where a simple reversal of the CaM effect would be inhibition of the CICR. Furthermore, 100 μm TFP sensitized the CICR to Ca2+. A similar effect was produced by other CaM antagonists that were tested: chlorpromazine, W-7, mastoparan, and peptide fragment of CaM-binding residues of CaM-dependent protein kinase II. 3 The biphasic effect of CaM on the CICR was observed even in the presence of high concentrations of CaM antagonists or CaM-binding peptides. 4 From these results we suggest that CaM has a unique mode of action on the CICR which is quite different from the effect of CaM on known enzymes." @default.
• W2050853893 created "2016-06-24" @default.
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• W2050853893 date "1996-06-01" @default.
• W2050853893 modified "2023-10-18" @default.
• W2050853893 title "Effect of calmodulin antagonists on calmodulin-induced biphasic modulation of Ca2+-induced Ca2+ release" @default.
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• W2050853893 doi "https://doi.org/10.1111/j.1476-5381.1996.tb15455.x" @default.
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