FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050858217> ?p ?o ?g. }

• W2050858217 endingPage "R1109" @default.
• W2050858217 startingPage "R1102" @default.
• W2050858217 abstract "We studied the importance of endothelium-derived hyperpolarizing factor (EDHF) vs. nitric oxide (NO) and prostacyclin (PGI(2)) in bradykinin (BK)-induced relaxation in isolated small subcutaneous arteries from normal pregnant women. We also explored the contribution of cytochrome P-450 (CYP450) product of arachidonic acid (AA) metabolism, hydrogen peroxide (H(2)O(2)), and gap junctions that have been suggested to be involved in EDHF-mediated responses. Isolated arteries obtained from subcutaneous fat biopsies of normal pregnant women (n = 30) undergoing planned cesarean section were mounted in a wire-myography system. In norepinephrine-constricted vessels, incubation with N(G)-nitro-L-arginine methyl ester (L-NAME) resulted in a significant reduction in relaxation to BK. Simultaneous incubation with L-NAME and indomethacin failed to modify this response further. BK-mediated dilatation in the presence of K(+)-modified solution was decreased to similar level as obtained after incubation with L-NAME. Incubation with L-NAME abolished BK-induced responses in K(+)-modified solution. Sulfaphenazole, a specific inhibitor of CYP450 epoxygenase, and catalase (an enzyme that decomposes H(2)O(2)) did not affect the EDHF-mediated relaxation because concentration-response curves to BK were similar in arteries after incubation with L-NAME vs. L-NAME + sulfaphenazole and L-NAME + catalase. The inhibitor of gap junctions, 18 alpha-glycyrrhetinic acid, significantly reduced BK-mediated relaxation both without and with incubation with L-NAME. We found that both NO and EDHF, but not PGI(2), are involved in the endothelium-dependent dilatation to BK. BK-induced relaxation is almost equally mediated by NO and EDHF. CYP450 epoxygenase metabolites of AA or H(2)O(2) do not account for EDHF-mediated response; however, gap junctions are involved in the EDHF-mediated responses to BK in subcutaneous small arteries in normal pregnancy." @default.
• W2050858217 created "2016-06-24" @default.
• W2050858217 creator A5006727116 @default.
• W2050858217 creator A5062254018 @default.
• W2050858217 creator A5072085702 @default.
• W2050858217 date "2004-06-01" @default.
• W2050858217 modified "2023-10-16" @default.
• W2050858217 title "The mechanism of EDHF-mediated responses in subcutaneous small arteries from healthy pregnant women" @default.
• W2050858217 cites W1546802604 @default.
• W2050858217 cites W1851810649 @default.
• W2050858217 cites W1858680866 @default.
• W2050858217 cites W1971872550 @default.
• W2050858217 cites W1974330306 @default.
• W2050858217 cites W1974594344 @default.
• W2050858217 cites W1992303064 @default.
• W2050858217 cites W2006721601 @default.
• W2050858217 cites W2027662236 @default.
• W2050858217 cites W2041767355 @default.
• W2050858217 cites W2043024587 @default.
• W2050858217 cites W2044738766 @default.
• W2050858217 cites W2057677897 @default.
• W2050858217 cites W2067696654 @default.
• W2050858217 cites W2067872780 @default.
• W2050858217 cites W2069296756 @default.
• W2050858217 cites W2075629131 @default.
• W2050858217 cites W2079704184 @default.
• W2050858217 cites W2081056330 @default.
• W2050858217 cites W2082059445 @default.
• W2050858217 cites W2083959622 @default.
• W2050858217 cites W2092232971 @default.
• W2050858217 cites W2094545921 @default.
• W2050858217 cites W2099661048 @default.
• W2050858217 cites W2106303873 @default.
• W2050858217 cites W2116763228 @default.
• W2050858217 cites W2120899567 @default.
• W2050858217 cites W2132610709 @default.
• W2050858217 cites W2135609788 @default.
• W2050858217 cites W2138046394 @default.
• W2050858217 cites W2146056013 @default.
• W2050858217 cites W2147696607 @default.
• W2050858217 cites W2148887017 @default.
• W2050858217 cites W2161953383 @default.
• W2050858217 cites W2171129716 @default.
• W2050858217 cites W2315685912 @default.
• W2050858217 cites W4230944446 @default.
• W2050858217 cites W4243639332 @default.
• W2050858217 cites W4293586669 @default.
• W2050858217 cites W75021833 @default.
• W2050858217 doi "https://doi.org/10.1152/ajpregu.00550.2003" @default.
• W2050858217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14751845" @default.
• W2050858217 hasPublicationYear "2004" @default.
• W2050858217 type Work @default.
• W2050858217 sameAs 2050858217 @default.
• W2050858217 citedByCount "48" @default.
• W2050858217 countsByYear W20508582172012 @default.
• W2050858217 countsByYear W20508582172013 @default.
• W2050858217 countsByYear W20508582172014 @default.
• W2050858217 countsByYear W20508582172016 @default.
• W2050858217 countsByYear W20508582172017 @default.
• W2050858217 countsByYear W20508582172018 @default.
• W2050858217 countsByYear W20508582172020 @default.
• W2050858217 countsByYear W20508582172021 @default.
• W2050858217 countsByYear W20508582172022 @default.
• W2050858217 crossrefType "journal-article" @default.
• W2050858217 hasAuthorship W2050858217A5006727116 @default.
• W2050858217 hasAuthorship W2050858217A5062254018 @default.
• W2050858217 hasAuthorship W2050858217A5072085702 @default.
• W2050858217 hasConcept C120770815 @default.
• W2050858217 hasConcept C126322002 @default.
• W2050858217 hasConcept C134018914 @default.
• W2050858217 hasConcept C170493617 @default.
• W2050858217 hasConcept C181199279 @default.
• W2050858217 hasConcept C185592680 @default.
• W2050858217 hasConcept C25642318 @default.
• W2050858217 hasConcept C2776820930 @default.
• W2050858217 hasConcept C2776992346 @default.
• W2050858217 hasConcept C2778078955 @default.
• W2050858217 hasConcept C2779411790 @default.
• W2050858217 hasConcept C2779591629 @default.
• W2050858217 hasConcept C2779689624 @default.
• W2050858217 hasConcept C2780419564 @default.
• W2050858217 hasConcept C2780664492 @default.
• W2050858217 hasConcept C2780733407 @default.
• W2050858217 hasConcept C2780771799 @default.
• W2050858217 hasConcept C2781128415 @default.
• W2050858217 hasConcept C42219234 @default.
• W2050858217 hasConcept C519581460 @default.
• W2050858217 hasConcept C55493867 @default.
• W2050858217 hasConcept C71924100 @default.
• W2050858217 hasConceptScore W2050858217C120770815 @default.
• W2050858217 hasConceptScore W2050858217C126322002 @default.
• W2050858217 hasConceptScore W2050858217C134018914 @default.
• W2050858217 hasConceptScore W2050858217C170493617 @default.
• W2050858217 hasConceptScore W2050858217C181199279 @default.
• W2050858217 hasConceptScore W2050858217C185592680 @default.
• W2050858217 hasConceptScore W2050858217C25642318 @default.
• W2050858217 hasConceptScore W2050858217C2776820930 @default.
• W2050858217 hasConceptScore W2050858217C2776992346 @default.

• next