Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050866306> ?p ?o ?g. }
- W2050866306 endingPage "5010" @default.
- W2050866306 startingPage "4995" @default.
- W2050866306 abstract "A series of aza inhibitors (4–9) of chorismate mutase (E.C. 5.4.99.5) was designed, prepared, and evaluated against the enzyme by monitoring the direct inhibition of the chorismate, 1, to prephenate, 2, conversion. None of these aza inhibitors displayed tighter binding to the enzyme than the native substrate chorismate or greater inhibitory action than the previously reported ether analogue, 3. Furthermore, no time-dependent loss of enzyme activity was observed in the presence of the two potentially reactive aza inhibitors (7 and 9). These results in conjunction with inhibition data from a broader series of chorismate mutase inhibitors allowed a novel proposal for the mechanistic role of chorismate mutase to be developed. This proposed mechanism was computationally verified and correlated with crystallographic studies of various chorismate mutases." @default.
- W2050866306 created "2016-06-24" @default.
- W2050866306 creator A5078816672 @default.
- W2050866306 date "2004-09-01" @default.
- W2050866306 modified "2023-09-27" @default.
- W2050866306 title "Design, synthesis, and evaluation of aza inhibitors of chorismate mutase" @default.
- W2050866306 cites W1568288844 @default.
- W2050866306 cites W1784952320 @default.
- W2050866306 cites W1967579508 @default.
- W2050866306 cites W1968749056 @default.
- W2050866306 cites W1970340187 @default.
- W2050866306 cites W1978259017 @default.
- W2050866306 cites W1982427518 @default.
- W2050866306 cites W1983381627 @default.
- W2050866306 cites W1988572437 @default.
- W2050866306 cites W1992796227 @default.
- W2050866306 cites W1996779761 @default.
- W2050866306 cites W2000488517 @default.
- W2050866306 cites W2002292771 @default.
- W2050866306 cites W2006237105 @default.
- W2050866306 cites W2010437243 @default.
- W2050866306 cites W2012404011 @default.
- W2050866306 cites W2015993457 @default.
- W2050866306 cites W2016268293 @default.
- W2050866306 cites W2016380870 @default.
- W2050866306 cites W2022570131 @default.
- W2050866306 cites W2028430491 @default.
- W2050866306 cites W2033394643 @default.
- W2050866306 cites W2037162409 @default.
- W2050866306 cites W2037454977 @default.
- W2050866306 cites W2041467079 @default.
- W2050866306 cites W2042635510 @default.
- W2050866306 cites W2043582941 @default.
- W2050866306 cites W2047476024 @default.
- W2050866306 cites W2047645546 @default.
- W2050866306 cites W2066412931 @default.
- W2050866306 cites W2067310286 @default.
- W2050866306 cites W2069607377 @default.
- W2050866306 cites W2070547238 @default.
- W2050866306 cites W2072619761 @default.
- W2050866306 cites W2077610712 @default.
- W2050866306 cites W2080941881 @default.
- W2050866306 cites W2081077157 @default.
- W2050866306 cites W2081198332 @default.
- W2050866306 cites W2139044055 @default.
- W2050866306 cites W2161469843 @default.
- W2050866306 cites W2162959060 @default.
- W2050866306 cites W3196052304 @default.
- W2050866306 cites W4231365453 @default.
- W2050866306 cites W4243434350 @default.
- W2050866306 cites W4245335048 @default.
- W2050866306 doi "https://doi.org/10.1016/j.bmc.2004.06.037" @default.
- W2050866306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15336279" @default.
- W2050866306 hasPublicationYear "2004" @default.
- W2050866306 type Work @default.
- W2050866306 sameAs 2050866306 @default.
- W2050866306 citedByCount "27" @default.
- W2050866306 countsByYear W20508663062012 @default.
- W2050866306 countsByYear W20508663062013 @default.
- W2050866306 countsByYear W20508663062014 @default.
- W2050866306 countsByYear W20508663062016 @default.
- W2050866306 countsByYear W20508663062017 @default.
- W2050866306 countsByYear W20508663062018 @default.
- W2050866306 countsByYear W20508663062021 @default.
- W2050866306 countsByYear W20508663062023 @default.
- W2050866306 crossrefType "journal-article" @default.
- W2050866306 hasAuthorship W2050866306A5078816672 @default.
- W2050866306 hasConcept C181199279 @default.
- W2050866306 hasConcept C185592680 @default.
- W2050866306 hasConcept C2777552656 @default.
- W2050866306 hasConcept C2778526059 @default.
- W2050866306 hasConcept C41183919 @default.
- W2050866306 hasConcept C553450214 @default.
- W2050866306 hasConcept C55493867 @default.
- W2050866306 hasConcept C71240020 @default.
- W2050866306 hasConceptScore W2050866306C181199279 @default.
- W2050866306 hasConceptScore W2050866306C185592680 @default.
- W2050866306 hasConceptScore W2050866306C2777552656 @default.
- W2050866306 hasConceptScore W2050866306C2778526059 @default.
- W2050866306 hasConceptScore W2050866306C41183919 @default.
- W2050866306 hasConceptScore W2050866306C553450214 @default.
- W2050866306 hasConceptScore W2050866306C55493867 @default.
- W2050866306 hasConceptScore W2050866306C71240020 @default.
- W2050866306 hasIssue "18" @default.
- W2050866306 hasLocation W20508663061 @default.
- W2050866306 hasLocation W20508663062 @default.
- W2050866306 hasOpenAccess W2050866306 @default.
- W2050866306 hasPrimaryLocation W20508663061 @default.
- W2050866306 hasRelatedWork W1139442884 @default.
- W2050866306 hasRelatedWork W1485892674 @default.
- W2050866306 hasRelatedWork W1492762973 @default.
- W2050866306 hasRelatedWork W1523382491 @default.
- W2050866306 hasRelatedWork W1861462068 @default.
- W2050866306 hasRelatedWork W1966307757 @default.
- W2050866306 hasRelatedWork W2005231748 @default.
- W2050866306 hasRelatedWork W2032770869 @default.
- W2050866306 hasRelatedWork W2139074253 @default.
- W2050866306 hasRelatedWork W2945066081 @default.