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- W2050871134 abstract "A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was tested with trimethoprim/sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) or the suppository dose absorbed for TMP and SMX were 3.0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained." @default.
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- W2050871134 date "1981-02-01" @default.
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- W2050871134 title "Poor rectal absorption of trimethoprim/sulphamethoxazole in treating <i>Pneumocystis carinii</i> pneumonia" @default.
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- W2050871134 doi "https://doi.org/10.1136/pgmj.57.664.123" @default.
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