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- W2050871155 abstract "Aim: Treg cells have been identified to play an important role in regulating T-cell responses and thereby affecting the Th1/Th2 cytokine balance. However, their role in periodontal disease is yet to be identified. Alterations in the expression of regulatory T cells in periodontal tissues could result in a change in their systemic levels. The aim of the study was to identify the regulatory T-cell subsets in systemic circulation and to compare their levels in patients with periodontal health and disease. Materials and Methods: Thirty-five peripheral blood samples were collected from each of two groups of patients (periodontal health: Group A, and periodontal disease: Group B). The samples were processed for flow cytometric analysis to detect and compare the expression of Treg cells (regulatory T cells). Statistical analysis was done using the Student's t test. Results: The mean Treg cells for the health group (Group A) was 311,724 cells/ml with a standard deviation of 250,411. The mean Treg cells for the disease group (Group B) was 260,809 cells/ml with a standard deviation of 187,900. P value was 0.508, which is statistically not significant. Conclusion: There is no statistically significant difference between Treg cell levels in periodontal health and disease, with respect to systemic circulation, although there is a slight decrease in levels in periodontitis compared to health. Apart from Th1/Th2 cells, the regulatory T cells may also contribute to the overall T-cell phenotype. Further studies are needed to confirm this hypothesis." @default.
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- W2050871155 date "2012-01-01" @default.
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- W2050871155 title "Comparison of systemic levels of regulatory T cells in periodontal health and disease" @default.
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- W2050871155 doi "https://doi.org/10.4103/2277-8632.102440" @default.
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