Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050871402> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2050871402 endingPage "151" @default.
- W2050871402 startingPage "145" @default.
- W2050871402 abstract "The tumor microenvironment is complex and creates an immunosuppressive network to tolerize tumor-specific immune responses; however, little information is available regarding the response against non-tumor antigens in tumor-bearing individuals. The goal of the present study was to evaluate if tumor burden could influence a CD4+ T cell response against a soluble protein, not expressed by the tumor, in the absence of in vitro stimulation. Using an experimental system in which we can compare CD4+ T cell responses to the Ea antigen when it is either expressed by B16F10 melanoma cells (B16EaRFP cells) or is an exogenous, non-tumor antigen (soluble EaRFP protein), in immunizations of B16F10 tumor-bearing mice, we observed that the tumor can modulate the CD4+ T cell-specific response to the antigen when it is expressed by the tumor cells. TEa cells proliferated poorly and produced less IFN-γ in mice bearing B16F10 melanoma expressing Ea peptide, and tumor growth was impervious to this response. However, in mice bearing 7 days B16F10 tumors, not expressing the Ea antigen, priming of TEa cells was similar to that observed in tumor-free mice, based on the total number of cells recovered and proliferation assessed by CFSE dilution after EaRFP immunization. We also investigated if tumor burden could influence recall responses of already differentiated effector cells. We immunized mice with EaRFP antigen and after a few days injected B16F10 cells. After 10 days of tumor growth, we challenged the mice with the non-tumor antigen. We found that the number of TEa cells producing IFN-γ in tumor-bearing mice was not different compared to tumor-free mice. No differences in antigen presentation, assessed by YAe antibody staining, were verified in the draining lymph node of these two groups. Collectively, our data indicate that tumor burden does not affect immune responses to non-tumor antigens. These results have important implications in the design of anti-cancer therapy." @default.
- W2050871402 created "2016-06-24" @default.
- W2050871402 creator A5003943728 @default.
- W2050871402 creator A5024467521 @default.
- W2050871402 creator A5042204528 @default.
- W2050871402 creator A5083723386 @default.
- W2050871402 date "2010-10-21" @default.
- W2050871402 modified "2023-10-18" @default.
- W2050871402 title "CD4+ T cell response against a non-tumor antigen is unaffected in melanoma-bearing mice" @default.
- W2050871402 cites W1521600055 @default.
- W2050871402 cites W1625062092 @default.
- W2050871402 cites W1978772108 @default.
- W2050871402 cites W1987589866 @default.
- W2050871402 cites W1989963588 @default.
- W2050871402 cites W2001093589 @default.
- W2050871402 cites W2016827757 @default.
- W2050871402 cites W2018968534 @default.
- W2050871402 cites W2023491212 @default.
- W2050871402 cites W2057427371 @default.
- W2050871402 cites W2074643855 @default.
- W2050871402 cites W2085402152 @default.
- W2050871402 cites W2090555105 @default.
- W2050871402 cites W2097074641 @default.
- W2050871402 cites W2111220263 @default.
- W2050871402 cites W2119900303 @default.
- W2050871402 cites W2120212813 @default.
- W2050871402 cites W2128564429 @default.
- W2050871402 cites W2134918129 @default.
- W2050871402 cites W2146437446 @default.
- W2050871402 cites W2148817537 @default.
- W2050871402 cites W2159116335 @default.
- W2050871402 cites W2160166896 @default.
- W2050871402 cites W2335128695 @default.
- W2050871402 doi "https://doi.org/10.1007/s00262-010-0922-1" @default.
- W2050871402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20963412" @default.
- W2050871402 hasPublicationYear "2010" @default.
- W2050871402 type Work @default.
- W2050871402 sameAs 2050871402 @default.
- W2050871402 citedByCount "0" @default.
- W2050871402 crossrefType "journal-article" @default.
- W2050871402 hasAuthorship W2050871402A5003943728 @default.
- W2050871402 hasAuthorship W2050871402A5024467521 @default.
- W2050871402 hasAuthorship W2050871402A5042204528 @default.
- W2050871402 hasAuthorship W2050871402A5083723386 @default.
- W2050871402 hasBestOaLocation W20508714021 @default.
- W2050871402 hasConcept C100701293 @default.
- W2050871402 hasConcept C147483822 @default.
- W2050871402 hasConcept C154317977 @default.
- W2050871402 hasConcept C202751555 @default.
- W2050871402 hasConcept C203014093 @default.
- W2050871402 hasConcept C2776090121 @default.
- W2050871402 hasConcept C2776107976 @default.
- W2050871402 hasConcept C2776662205 @default.
- W2050871402 hasConcept C2777658100 @default.
- W2050871402 hasConcept C2777701055 @default.
- W2050871402 hasConcept C502942594 @default.
- W2050871402 hasConcept C55493867 @default.
- W2050871402 hasConcept C59822182 @default.
- W2050871402 hasConcept C81444415 @default.
- W2050871402 hasConcept C86803240 @default.
- W2050871402 hasConcept C8891405 @default.
- W2050871402 hasConceptScore W2050871402C100701293 @default.
- W2050871402 hasConceptScore W2050871402C147483822 @default.
- W2050871402 hasConceptScore W2050871402C154317977 @default.
- W2050871402 hasConceptScore W2050871402C202751555 @default.
- W2050871402 hasConceptScore W2050871402C203014093 @default.
- W2050871402 hasConceptScore W2050871402C2776090121 @default.
- W2050871402 hasConceptScore W2050871402C2776107976 @default.
- W2050871402 hasConceptScore W2050871402C2776662205 @default.
- W2050871402 hasConceptScore W2050871402C2777658100 @default.
- W2050871402 hasConceptScore W2050871402C2777701055 @default.
- W2050871402 hasConceptScore W2050871402C502942594 @default.
- W2050871402 hasConceptScore W2050871402C55493867 @default.
- W2050871402 hasConceptScore W2050871402C59822182 @default.
- W2050871402 hasConceptScore W2050871402C81444415 @default.
- W2050871402 hasConceptScore W2050871402C86803240 @default.
- W2050871402 hasConceptScore W2050871402C8891405 @default.
- W2050871402 hasIssue "1" @default.
- W2050871402 hasLocation W20508714021 @default.
- W2050871402 hasLocation W20508714022 @default.
- W2050871402 hasOpenAccess W2050871402 @default.
- W2050871402 hasPrimaryLocation W20508714021 @default.
- W2050871402 hasRelatedWork W1517459791 @default.
- W2050871402 hasRelatedWork W2614005222 @default.
- W2050871402 hasRelatedWork W2898701288 @default.
- W2050871402 hasRelatedWork W3004954919 @default.
- W2050871402 hasRelatedWork W3039388108 @default.
- W2050871402 hasRelatedWork W3158438576 @default.
- W2050871402 hasRelatedWork W4304979265 @default.
- W2050871402 hasRelatedWork W4312075079 @default.
- W2050871402 hasRelatedWork W4327715451 @default.
- W2050871402 hasRelatedWork W4366185366 @default.
- W2050871402 hasVolume "60" @default.
- W2050871402 isParatext "false" @default.
- W2050871402 isRetracted "false" @default.
- W2050871402 magId "2050871402" @default.
- W2050871402 workType "article" @default.