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- W2050872220 abstract "Abstract SAMP1 is a line of inbred mice with a pronounced misbalance between generation and neutralization of reactive oxygen species (ROS) in brain and other tissues. This results in accumulation of molecular defects in lipids, proteins and DNA moieties. The metabolic disorders appear at a very early stage of ontogenic development and induce morphological and behavioral defects manifesting from the fourth month after birth. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of these mice induced specific changes that closely resembled parkinsonian syndrome. Neuropeptide carnosine prevented toxic effects of MPTP and protected the animals against experimental parkinsonism." @default.
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- W2050872220 date "2004-02-01" @default.
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- W2050872220 title "Chemical intervention in senescence-accelerated mice metabolism for modeling neurodegenerative diseases: an overview" @default.
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- W2050872220 doi "https://doi.org/10.1016/s0531-5131(03)01598-x" @default.
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