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• W2050872576 abstract "The hypothesis is presented, based on the chemical structure of neuromelanin, that one of its functions in the catecholamine neurons in the brain is to protect the cell against toxic quinones (such as dopaminochrome and noradrenochrome, or their dihydroxy isomers) produced from the catecholamines dopamine and noradrenaline (and possibly adrenaline) during the course of prostaglandin synthesis by the enzyme prostaglandin H synthetase, or possibly by spontaneous oxidation. One aminochrome–adrenochrome–has been shown to be neurotoxic and to have psychotomimetic properties in humans. Depending on the site of production these compounds may be involved in the pathogenesis of Parkinson’s disease or schizophrenia." @default.
• W2050872576 created "2016-06-24" @default.
• W2050872576 date "1996-04-22" @default.
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• W2050872576 title "On the function of neuromelanin" @default.
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• W2050872576 doi "https://doi.org/10.1098/rspb.1996.0073" @default.
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