Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050872725> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2050872725 endingPage "159" @default.
- W2050872725 startingPage "155" @default.
- W2050872725 abstract "Mechanisms regulating peptide neurotransmitter metabolism were examined in dissociated cell cultures of the neonatal rat superior cervical ganglion (SCG). The pineal gland, a target of the SCG, produced a soluble factor (PCM) which increased substance P (SP) levels more than 15-fold in sympathetic neurons cultured in the presence of ganglion non-neuronal cells. Elimination of the non-neuronal cells decreased SP to negligible levels and abolished the stimulatory effects of PCM on SP expression. These observations suggest that ganglion non-neuronal cells stimulate sympathetic expression of SP, and that the pineal influences neuronal SP by acting on, or in concert with, ganglion support cells. PCM also influenced other neurotransmitter systems. In the presence of ganglion non-neuronal cells, PCM treatment increased choline acetyltransferase (CHAC) and decreased tyrosine hydroxylase (TOH) and somatostatin (SO). By contrast, PCM treatment of pure neuronal cultures resulted in negligible CHAC and SP levels and a doubling of SO with a small increase in TOH. In sympathetic neurons, SP expression may be associated with cholinergic development, whereas SO may be associated with noradrenergic phenotypic expression. Moreover, there is a reciprocal relationship between SP and SS expression by sympathetic neurons analogous to the previously described relationship between noradrenergic and cholinergic expression." @default.
- W2050872725 created "2016-06-24" @default.
- W2050872725 creator A5029832154 @default.
- W2050872725 date "1984-10-01" @default.
- W2050872725 modified "2023-09-23" @default.
- W2050872725 title "Environmental co-regulation of substance P, somatostatin and neurotransmitter synthesizing enzymes in cultured sympathetic neurons" @default.
- W2050872725 cites W1528582206 @default.
- W2050872725 cites W1560023411 @default.
- W2050872725 cites W1561862275 @default.
- W2050872725 cites W1974104345 @default.
- W2050872725 cites W1977210892 @default.
- W2050872725 cites W1978238621 @default.
- W2050872725 cites W1983441282 @default.
- W2050872725 cites W1991881272 @default.
- W2050872725 cites W2001109963 @default.
- W2050872725 cites W2009373941 @default.
- W2050872725 cites W2015061197 @default.
- W2050872725 cites W2037270752 @default.
- W2050872725 cites W2051584920 @default.
- W2050872725 cites W2055831519 @default.
- W2050872725 cites W2058543880 @default.
- W2050872725 cites W2060223086 @default.
- W2050872725 cites W2066635530 @default.
- W2050872725 cites W2174825349 @default.
- W2050872725 doi "https://doi.org/10.1016/0006-8993(84)90693-0" @default.
- W2050872725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6208977" @default.
- W2050872725 hasPublicationYear "1984" @default.
- W2050872725 type Work @default.
- W2050872725 sameAs 2050872725 @default.
- W2050872725 citedByCount "37" @default.
- W2050872725 crossrefType "journal-article" @default.
- W2050872725 hasAuthorship W2050872725A5029832154 @default.
- W2050872725 hasConcept C118303440 @default.
- W2050872725 hasConcept C126322002 @default.
- W2050872725 hasConcept C134018914 @default.
- W2050872725 hasConcept C159167319 @default.
- W2050872725 hasConcept C169760540 @default.
- W2050872725 hasConcept C170493617 @default.
- W2050872725 hasConcept C185592680 @default.
- W2050872725 hasConcept C198399640 @default.
- W2050872725 hasConcept C22885893 @default.
- W2050872725 hasConcept C2775910092 @default.
- W2050872725 hasConcept C2776219046 @default.
- W2050872725 hasConcept C2776297358 @default.
- W2050872725 hasConcept C2776533618 @default.
- W2050872725 hasConcept C2777646271 @default.
- W2050872725 hasConcept C2778993773 @default.
- W2050872725 hasConcept C2781334511 @default.
- W2050872725 hasConcept C513476851 @default.
- W2050872725 hasConcept C529278444 @default.
- W2050872725 hasConcept C71924100 @default.
- W2050872725 hasConcept C86803240 @default.
- W2050872725 hasConceptScore W2050872725C118303440 @default.
- W2050872725 hasConceptScore W2050872725C126322002 @default.
- W2050872725 hasConceptScore W2050872725C134018914 @default.
- W2050872725 hasConceptScore W2050872725C159167319 @default.
- W2050872725 hasConceptScore W2050872725C169760540 @default.
- W2050872725 hasConceptScore W2050872725C170493617 @default.
- W2050872725 hasConceptScore W2050872725C185592680 @default.
- W2050872725 hasConceptScore W2050872725C198399640 @default.
- W2050872725 hasConceptScore W2050872725C22885893 @default.
- W2050872725 hasConceptScore W2050872725C2775910092 @default.
- W2050872725 hasConceptScore W2050872725C2776219046 @default.
- W2050872725 hasConceptScore W2050872725C2776297358 @default.
- W2050872725 hasConceptScore W2050872725C2776533618 @default.
- W2050872725 hasConceptScore W2050872725C2777646271 @default.
- W2050872725 hasConceptScore W2050872725C2778993773 @default.
- W2050872725 hasConceptScore W2050872725C2781334511 @default.
- W2050872725 hasConceptScore W2050872725C513476851 @default.
- W2050872725 hasConceptScore W2050872725C529278444 @default.
- W2050872725 hasConceptScore W2050872725C71924100 @default.
- W2050872725 hasConceptScore W2050872725C86803240 @default.
- W2050872725 hasIssue "1" @default.
- W2050872725 hasLocation W20508727251 @default.
- W2050872725 hasLocation W20508727252 @default.
- W2050872725 hasOpenAccess W2050872725 @default.
- W2050872725 hasPrimaryLocation W20508727251 @default.
- W2050872725 hasRelatedWork W1997821206 @default.
- W2050872725 hasRelatedWork W2014279663 @default.
- W2050872725 hasRelatedWork W2039901629 @default.
- W2050872725 hasRelatedWork W2046343911 @default.
- W2050872725 hasRelatedWork W2050872725 @default.
- W2050872725 hasRelatedWork W2076832669 @default.
- W2050872725 hasRelatedWork W2083574273 @default.
- W2050872725 hasRelatedWork W2418800366 @default.
- W2050872725 hasRelatedWork W2472970117 @default.
- W2050872725 hasRelatedWork W44071019 @default.
- W2050872725 hasVolume "321" @default.
- W2050872725 isParatext "false" @default.
- W2050872725 isRetracted "false" @default.
- W2050872725 magId "2050872725" @default.
- W2050872725 workType "article" @default.