Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050874722> ?p ?o ?g. }
- W2050874722 endingPage "756" @default.
- W2050874722 startingPage "749" @default.
- W2050874722 abstract "We have previously demonstrated that severe adipose tissue atrophy occurs upon dietary treatment of mice with potent peroxisome proliferators (PPs). This atrophy occurs subsequent to peroxisome proliferation in the liver and may represent a novel addition to the pleiotropic effects exerted by PPs. In the present study we have characterized the recovery of mice from such atrophy following cessation of exposure. Following termination of treatment with perfluorooctanoic acid (PFOA) for 7 days, the adipose tissue atrophy was rapidly reversed, beginning on 2-5 days of recovery and being complete within 10 days. In contrast, hepatic peroxisome proliferation recovered much more slowly, indicating that these processes are not strictly coordinated. Analysis of lipoprotein lipase and hormone-sensitive lipase activities in adipose tissue revealed that the decrease and increase in these activities, respectively, caused by PFOA were both reversed within 10 days of recovery. Overall, these data provide further support for our previous conclusion that the adipose tissue atrophy induced by PFOA is caused, at least in part, by changes in the activities of lipoprotein lipase and hormone-sensitive lipase. The serum level of cholesterol, which increased after termination of PFOA treatment, returned to normal with a time-course similar to the recovery of adipose tissue weight, although hepatic peroxisome proliferation was still present. The possible relationship between the reduction in serum cholesterol and/or in its availability to peripheral tissues and the associated atrophy of adipose tissues caused by PPs is discussed." @default.
- W2050874722 created "2016-06-24" @default.
- W2050874722 creator A5024079940 @default.
- W2050874722 creator A5069475444 @default.
- W2050874722 creator A5074683975 @default.
- W2050874722 creator A5085110606 @default.
- W2050874722 date "2003-09-01" @default.
- W2050874722 modified "2023-09-23" @default.
- W2050874722 title "The relationship between liver peroxisome proliferation and adipose tissue atrophy induced by peroxisome proliferator exposure and withdrawal in mice" @default.
- W2050874722 cites W1775749144 @default.
- W2050874722 cites W1822687991 @default.
- W2050874722 cites W1947043095 @default.
- W2050874722 cites W1968912013 @default.
- W2050874722 cites W1973713357 @default.
- W2050874722 cites W1977765460 @default.
- W2050874722 cites W1983339091 @default.
- W2050874722 cites W1996905851 @default.
- W2050874722 cites W2004441812 @default.
- W2050874722 cites W2021988516 @default.
- W2050874722 cites W2030693139 @default.
- W2050874722 cites W2032809711 @default.
- W2050874722 cites W2051278645 @default.
- W2050874722 cites W2052701716 @default.
- W2050874722 cites W2054805984 @default.
- W2050874722 cites W2054851194 @default.
- W2050874722 cites W2057474602 @default.
- W2050874722 cites W2057958796 @default.
- W2050874722 cites W2064715676 @default.
- W2050874722 cites W2081318196 @default.
- W2050874722 cites W2083811960 @default.
- W2050874722 cites W2121346652 @default.
- W2050874722 cites W2125094939 @default.
- W2050874722 cites W2128268842 @default.
- W2050874722 cites W2130153256 @default.
- W2050874722 cites W2131037449 @default.
- W2050874722 cites W2137046761 @default.
- W2050874722 cites W2144718273 @default.
- W2050874722 cites W2276225229 @default.
- W2050874722 cites W2316297210 @default.
- W2050874722 cites W2325113820 @default.
- W2050874722 doi "https://doi.org/10.1016/s0006-2952(03)00386-1" @default.
- W2050874722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12948855" @default.
- W2050874722 hasPublicationYear "2003" @default.
- W2050874722 type Work @default.
- W2050874722 sameAs 2050874722 @default.
- W2050874722 citedByCount "44" @default.
- W2050874722 countsByYear W20508747222012 @default.
- W2050874722 countsByYear W20508747222013 @default.
- W2050874722 countsByYear W20508747222015 @default.
- W2050874722 countsByYear W20508747222017 @default.
- W2050874722 countsByYear W20508747222018 @default.
- W2050874722 countsByYear W20508747222019 @default.
- W2050874722 countsByYear W20508747222020 @default.
- W2050874722 countsByYear W20508747222021 @default.
- W2050874722 countsByYear W20508747222022 @default.
- W2050874722 countsByYear W20508747222023 @default.
- W2050874722 crossrefType "journal-article" @default.
- W2050874722 hasAuthorship W2050874722A5024079940 @default.
- W2050874722 hasAuthorship W2050874722A5069475444 @default.
- W2050874722 hasAuthorship W2050874722A5074683975 @default.
- W2050874722 hasAuthorship W2050874722A5085110606 @default.
- W2050874722 hasConcept C126322002 @default.
- W2050874722 hasConcept C127078168 @default.
- W2050874722 hasConcept C134018914 @default.
- W2050874722 hasConcept C151955695 @default.
- W2050874722 hasConcept C170493617 @default.
- W2050874722 hasConcept C171089720 @default.
- W2050874722 hasConcept C185592680 @default.
- W2050874722 hasConcept C2780613262 @default.
- W2050874722 hasConcept C2781172350 @default.
- W2050874722 hasConcept C511355011 @default.
- W2050874722 hasConcept C71924100 @default.
- W2050874722 hasConcept C86803240 @default.
- W2050874722 hasConcept C94879076 @default.
- W2050874722 hasConceptScore W2050874722C126322002 @default.
- W2050874722 hasConceptScore W2050874722C127078168 @default.
- W2050874722 hasConceptScore W2050874722C134018914 @default.
- W2050874722 hasConceptScore W2050874722C151955695 @default.
- W2050874722 hasConceptScore W2050874722C170493617 @default.
- W2050874722 hasConceptScore W2050874722C171089720 @default.
- W2050874722 hasConceptScore W2050874722C185592680 @default.
- W2050874722 hasConceptScore W2050874722C2780613262 @default.
- W2050874722 hasConceptScore W2050874722C2781172350 @default.
- W2050874722 hasConceptScore W2050874722C511355011 @default.
- W2050874722 hasConceptScore W2050874722C71924100 @default.
- W2050874722 hasConceptScore W2050874722C86803240 @default.
- W2050874722 hasConceptScore W2050874722C94879076 @default.
- W2050874722 hasIssue "5" @default.
- W2050874722 hasLocation W20508747221 @default.
- W2050874722 hasLocation W20508747222 @default.
- W2050874722 hasOpenAccess W2050874722 @default.
- W2050874722 hasPrimaryLocation W20508747221 @default.
- W2050874722 hasRelatedWork W2025731911 @default.
- W2050874722 hasRelatedWork W2077675220 @default.
- W2050874722 hasRelatedWork W2099969362 @default.
- W2050874722 hasRelatedWork W2106014044 @default.
- W2050874722 hasRelatedWork W2106570883 @default.
- W2050874722 hasRelatedWork W2132268865 @default.