Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050878068> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2050878068 endingPage "S24" @default.
- W2050878068 startingPage "S20" @default.
- W2050878068 abstract "Despite the current trend toward monotherapy, polytherapy in children with epilepsy is still common. A drug combination is advantageous only if it achieves a higher efficacy:toxicity ratio (therapeutic index) or if its antiepileptic spectrum is wider. Studies of brain concentrations of antiepileptic drugs have so far shown that a higher efficacy:toxicity ratio is not achieved by most combinations. Problems are associated with drug combinations. First, numerous pharmacokinetic interactions are documented. These interactions, which can be associated with significant changes in blood levels at a given dose, make frequent measurements and dosage readjustments necessary. They can also alter the concentration of active metabolites or the free fraction of a drug. Second, toxicity can be assumed to be at least partially cumulative, since reduction in polytherapy has been shown to be associated with a reduction in side effects. Third, the therapeutic range appears to depend on whether a drug is taken alone or in combination, so that polytherapy confuses the interpretation of serum drug measurements. Fourth, the presence of more than one drug will add to the difficulty in evaluating the efficacy or side effects of any single drug. Finally, a pharmacodynamic interaction between valproate and several other antiepileptics, particularly the barbiturates, can lead to a stuporous state. Transition from polytherapy to monotherapy is much more difficult to achieve than the opposite." @default.
- W2050878068 created "2016-06-24" @default.
- W2050878068 creator A5026925261 @default.
- W2050878068 date "1988-12-01" @default.
- W2050878068 modified "2023-10-16" @default.
- W2050878068 title "Problems of Combination Drug Therapy in Children" @default.
- W2050878068 cites W1971779178 @default.
- W2050878068 cites W1978301229 @default.
- W2050878068 cites W1978444610 @default.
- W2050878068 cites W1980326346 @default.
- W2050878068 cites W1992005798 @default.
- W2050878068 cites W1995451292 @default.
- W2050878068 cites W1996143761 @default.
- W2050878068 cites W2004021627 @default.
- W2050878068 cites W2031325622 @default.
- W2050878068 cites W2036186717 @default.
- W2050878068 cites W2036320366 @default.
- W2050878068 cites W2038922474 @default.
- W2050878068 cites W2040964477 @default.
- W2050878068 cites W2045982437 @default.
- W2050878068 cites W2047827560 @default.
- W2050878068 cites W2051299701 @default.
- W2050878068 cites W2057926710 @default.
- W2050878068 cites W2078823695 @default.
- W2050878068 cites W2082863354 @default.
- W2050878068 cites W2082883859 @default.
- W2050878068 cites W2085083777 @default.
- W2050878068 cites W2095355443 @default.
- W2050878068 cites W2099608272 @default.
- W2050878068 cites W2111826761 @default.
- W2050878068 cites W2131669512 @default.
- W2050878068 cites W2146298388 @default.
- W2050878068 cites W2149335723 @default.
- W2050878068 cites W2151563871 @default.
- W2050878068 cites W2153335219 @default.
- W2050878068 cites W2158079444 @default.
- W2050878068 cites W2158713352 @default.
- W2050878068 doi "https://doi.org/10.1111/j.1528-1157.1988.tb05806.x" @default.
- W2050878068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3066617" @default.
- W2050878068 hasPublicationYear "1988" @default.
- W2050878068 type Work @default.
- W2050878068 sameAs 2050878068 @default.
- W2050878068 citedByCount "16" @default.
- W2050878068 crossrefType "journal-article" @default.
- W2050878068 hasAuthorship W2050878068A5026925261 @default.
- W2050878068 hasConcept C111113717 @default.
- W2050878068 hasConcept C112705442 @default.
- W2050878068 hasConcept C118552586 @default.
- W2050878068 hasConcept C126322002 @default.
- W2050878068 hasConcept C149172746 @default.
- W2050878068 hasConcept C19831878 @default.
- W2050878068 hasConcept C2776999253 @default.
- W2050878068 hasConcept C2778186239 @default.
- W2050878068 hasConcept C2780035454 @default.
- W2050878068 hasConcept C2780272996 @default.
- W2050878068 hasConcept C29730261 @default.
- W2050878068 hasConcept C42219234 @default.
- W2050878068 hasConcept C71924100 @default.
- W2050878068 hasConcept C97320921 @default.
- W2050878068 hasConcept C98274493 @default.
- W2050878068 hasConceptScore W2050878068C111113717 @default.
- W2050878068 hasConceptScore W2050878068C112705442 @default.
- W2050878068 hasConceptScore W2050878068C118552586 @default.
- W2050878068 hasConceptScore W2050878068C126322002 @default.
- W2050878068 hasConceptScore W2050878068C149172746 @default.
- W2050878068 hasConceptScore W2050878068C19831878 @default.
- W2050878068 hasConceptScore W2050878068C2776999253 @default.
- W2050878068 hasConceptScore W2050878068C2778186239 @default.
- W2050878068 hasConceptScore W2050878068C2780035454 @default.
- W2050878068 hasConceptScore W2050878068C2780272996 @default.
- W2050878068 hasConceptScore W2050878068C29730261 @default.
- W2050878068 hasConceptScore W2050878068C42219234 @default.
- W2050878068 hasConceptScore W2050878068C71924100 @default.
- W2050878068 hasConceptScore W2050878068C97320921 @default.
- W2050878068 hasConceptScore W2050878068C98274493 @default.
- W2050878068 hasIssue "s3" @default.
- W2050878068 hasLocation W20508780681 @default.
- W2050878068 hasLocation W20508780682 @default.
- W2050878068 hasOpenAccess W2050878068 @default.
- W2050878068 hasPrimaryLocation W20508780681 @default.
- W2050878068 hasRelatedWork W1945821990 @default.
- W2050878068 hasRelatedWork W1991677481 @default.
- W2050878068 hasRelatedWork W2050878068 @default.
- W2050878068 hasRelatedWork W2071747460 @default.
- W2050878068 hasRelatedWork W2227061539 @default.
- W2050878068 hasRelatedWork W2414126392 @default.
- W2050878068 hasRelatedWork W2420918848 @default.
- W2050878068 hasRelatedWork W2567767604 @default.
- W2050878068 hasRelatedWork W2947400827 @default.
- W2050878068 hasRelatedWork W3024433273 @default.
- W2050878068 hasVolume "29" @default.
- W2050878068 isParatext "false" @default.
- W2050878068 isRetracted "false" @default.
- W2050878068 magId "2050878068" @default.
- W2050878068 workType "article" @default.